PMID: 6403772Apr 1, 1983Paper

A controlled, randomized trial evaluating the effects of enteral and parenteral nutrition on protein metabolism in cancer-bearing man

The Journal of Surgical Research
M E BurtM F Brennan

Abstract

To characterize the effects of enteral versus parenteral nutritional support on protein metabolism in the cancer patient, patients with localized, squamous cell carcinoma of the distal esophagus were randomized to receive nutritional support as follows: (1) if there was a loss of less than 20% of the preillness body weight, patients were randomized to continue eating ad libitum (group I) versus receiving total parenteral nutrition (TPN) (group II); (2) if there was a loss greater than 20% of the preillness body weight and/or the patient was unable to swallow, patients were randomized to jejunostomy feedings (group III) versus TPN (group IV). Patients were initially studied in the postabsorptive state and again 2 weeks after beginning, and while receiving, enteral or parenteral feedings. Stable isotopic tracer methods utilizing constant infusion of [15N]glycine were used to determine whole-body protein turnover (flux), synthesis, and catabolism. Skeletal muscle catabolism was determined by measuring the urinary excretion of 3-methylhistidine and lean tissue mass was evaluated by determining total-body potassium by 40K whole-body scanning. Positive nitrogen balance was obtained in groups II and IV associated with significant weig...Continue Reading

References

Jan 1, 1979·Annals of Surgery·S F LowryM F Brennan
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Mar 1, 1981·Annals of Surgery·L H BarrM F Brennan
Feb 1, 1982·Surgery·P M StarkerJ M Kinney
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May 1, 1981·The Journal of Surgical Research·J A NortonM F Brennan
May 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·D M HickmanC F Frey

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Citations

Mar 1, 1993·World Journal of Surgery·C J Kelly, J M Daly
Jun 25, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Federico Bozzetti
Apr 21, 1998·Surgery Today·Y Sakurai, S Klein
Jun 30, 1984·Lancet·M JeevanandamM F Brennan
Jan 1, 1997·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J C Melchior
Jul 30, 1992·The New England Journal of Medicine·C Grunfeld, K R Feingold
Nov 1, 1987·The Journal of Clinical Investigation·H F StarnesM F Brennan
Jun 1, 1988·American Journal of Obstetrics and Gynecology·N M Spirtos, S C Ballon
Dec 12, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Federico Bozzetti, Valentina Bozzetti
May 30, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F BozzettiUNKNOWN ESPEN
Jan 31, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·L H Ellegård, I G Bosaeus
Feb 28, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J PengL-Q Chen
Apr 1, 1986·The Journal of Surgical Research·E B EnrioneM B Popp
Aug 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F Bozzetti
Jun 12, 2013·Critical Reviews in Oncology/hematology·Federico Bozzetti
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·P W Pisters, D B Pearlstone
Jan 10, 2017·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·R NasrahR T Jagoe
May 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·D B PearlstoneM Burt
May 20, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·T O Lipman
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·S M Ramos, P Lindine
Jul 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·F Bozzetti
Nov 11, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Federico Bozzetti
Jun 20, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Federico BozzettiPaolo Bossi
Jan 1, 1985·Medical Oncology and Tumor Pharmacotherapy·L Lindmark, L Ekman

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