A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers

International Journal of Pharmaceutics
Xiang LiWei-san Pan

Abstract

The objective of this study was to develop an ocular drug delivery system based on nanostructured lipid carrier and investigate its in vitro and in vivo characteristics. Ibuprofen was chosen as the model drug. Four different formulations of ibuprofen nanostructured lipid carriers were prepared by melted-ultrasonic methods; gelucire 44/14 was screened as one of the solid lipid matrix materials due to the good particle size dispersion and excellent contribution to the corneal permeability of the model drug. The modified Franz-type diffusion cells and isolated corneas were used in the test of drug corneal permeability and the in vivo releasing tests were carried out using microdialysis method. gelucire 44/14 and transcutol P could enhance the corneal permeability by different mechanisms. The corresponding apparent permeability coefficients (P(app)) were 1.28 and 1.36 times more than that of the control preparation. Stearylamine could prolong the pre-cornea retention time of the model drug to some extent. Ibuprofen nanostructured lipid carriers displayed controlled-release property. The AUC of the optimized formulation of ibuprofen nanostuctured lipid carriers was 3.99 times more than that of ibuprofen eye drops).

References

Jan 1, 1994·Journal of Pharmaceutical Sciences·D D Tang-LiuH Takruri
Dec 1, 2005·Drug Development and Industrial Pharmacy·Zhidong LiuJiawei Li

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Citations

Sep 8, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Chen YaoKaoxiang Sun
Jul 28, 2010·AAPS PharmSciTech·Dalapathi GugulothuVandana Patravale
Oct 17, 2012·AAPS PharmSciTech·Josimar de Oliveira EloyJuliana Maldonado Marchetti
Aug 12, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Neslihan Ustündağ-OkurGökhan Ertan
Oct 30, 2009·Journal of Liposome Research·Maria CarafaDaniela Monti
Oct 18, 2013·Journal of Liposome Research·Mahesh L BikkadNisharani S Ranpise
Feb 26, 2009·Expert Opinion on Drug Delivery·Slavomira Doktorovova, Eliana B Souto
May 25, 2010·Drug Delivery·Ali SeyfoddinRaida Al-Kassas
Mar 20, 2012·Drug Development and Industrial Pharmacy·Ali Seyfoddin, Raida Al-Kassas
Apr 26, 2012·Expert Opinion on Drug Delivery·Ebru Başaran, Yasemin Yazan
Jul 22, 2014·Expert Opinion on Drug Delivery·Andrea PensadoAlejandro Sanchez
Jul 6, 2010·Current Eye Research·Eliana B SoutoMaria Luisa Garcia
May 13, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Piyush JaiswalAmber Vyas
Oct 21, 2011·Journal of Pharmaceutical Sciences·Elisabet Gonzalez-MiraM Luisa García
Sep 28, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Ana BeloquiVéronique Préat
Aug 28, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ramesh C NagarwalJ K Pandit
May 12, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mona M A Abdel-MottalebAlf Lamprecht
Aug 20, 2010·Colloids and Surfaces. B, Biointerfaces·E Gonzalez-MiraE B Souto
Nov 27, 2015·Therapeutic Delivery·Rosario PignatelloGiovanni Puglisi
Oct 2, 2015·International Journal of Pharmaceutics·Jong-Suep BaekCheong-Weon Cho
Sep 2, 2015·International Journal of Pharmaceutics·Shilpa KakkarIndu Pal Kaur
Nov 28, 2012·Journal of Biomedical Materials Research. Part a·Mohd Abul KalamAws Alshamsan
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Salah El-SousiOctavio Díez-Sales
Nov 19, 2013·Journal of Applied Toxicology : JAT·Slavomira DoktorovovaPaula Martins-Lopes
May 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Oleh TaratulaTamara Minko
Jul 21, 2012·Pharmaceutical Development and Technology·Genç Lütfi, Demirel Müzeyyen
Apr 29, 2015·Pharmaceutical Development and Technology·Moses O OyewumiPrabodh Sadana
May 28, 2014·Journal of Microencapsulation·Kullavadee Karn-OrachaiUracha Rungsardthong Ruktanonchai
Jan 24, 2015·International Journal of Pharmaceutics·Shihui YuWeisan Pan
Jun 9, 2016·Colloids and Surfaces. B, Biointerfaces·Neeraj K GargOm Prakash Katare
Aug 2, 2016·Advanced Pharmaceutical Bulletin·Leila Azhar Shekoufeh Bahari, Hamed Hamishehkar

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