A controlled study of luteinizing hormone-releasing hormone agonist (buserelin) for the induction of folliculogenesis before in vitro fertilization

The New England Journal of Medicine
V MacLachlanD L Healy

Abstract

Treatment with clomiphene citrate and human menopausal gonadotropin (HMG) is often used to induce folliculogenesis before in vitro fertilization, but not all women have an adequate response. It has been hypothesized that abnormally high levels of luteinizing hormone (LH) may contribute to the reduced folliculogenesis. We therefore performed a controlled, open trial in which treatment with buserelin, an agonist of luteinizing hormone-releasing hormone citrate and HMG in 44 consecutive women in whom no oocytes or only one had been produced by standard treatment with clomiphene and HMG. Twenty-nine women received buserelin with HMG, and 15 received clomiphene citrate with HMG. The median number of oocytes per patient recovered from those who received buserelin with HMG was 4 (range, 0 to 19), as compared with 0 (range, 0 to 5) in those who received clomiphene citrate with HMG. The fertilization rates of oocytes recovered from both groups of patients were similar (75.8 percent and 76.5 percent, respectively). Fifty-four percent of patients given buserelin with HMG underwent triple-embryo transfer, as compared with 13 percent of those given clomiphene citrate with HMG. Pregnancy (n = 3) occurred only among the patients receiving bus...Continue Reading

References

Sep 1, 1977·The Journal of Clinical Endocrinology and Metabolism·J S Dericks-TanH D Taubert
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·I T CameronD L Healy
Apr 1, 1986·British Journal of Obstetrics and Gynaecology·D QuerleuG Crepin
Sep 1, 1980·British Journal of Obstetrics and Gynaecology·R G EdwardsJ M Purdy

❮ Previous
Next ❯

Citations

Nov 2, 2005·Journal of Gastroenterology·Alexandra AlexopoulouSpyros P Dourakis
Dec 30, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P CurtisR W Shaw
Jan 1, 1991·International Journal of Technology Assessment in Health Care·P A Lancaster
Jul 26, 2013·Human Reproduction Update·Theodoros N SergentanisEleni Th Petridou
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brian L SpragueDiana S M Buist
Jun 1, 1991·American Journal of Obstetrics and Gynecology·K A BurryP E Patton
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·B HedonF Laffargue
Jan 1, 1991·Annals of the New York Academy of Sciences·D L Healy
May 1, 1997·British Journal of Obstetrics and Gynaecology·S D KeayJ M Jenkins
Sep 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·P InaudiP De Grandi
Jun 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·O M AvrechB Fisch
Aug 20, 1990·The Medical Journal of Australia·R P JansenE Ciancaglini
Aug 20, 1990·The Medical Journal of Australia·R J Pepperell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gynécologie, obstétrique & fertilité
P MervielH Copin
European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
F ParazziniC La Vecchia
Expert Review of Anticancer Therapy
Giuseppe Lo RussoFederica Tomao
© 2022 Meta ULC. All rights reserved