A controlled trial of baclofen in children with cerebral palsy

The Journal of International Medical Research
P J Milla, A D Jackson

Abstract

A double-blind crossover trial against placebo was conducted to assess the effects of the GABA derivative, baclofen, on the disabilities due to muscle spasticity in twenty children suffering from cerebral palsy. Baclofen performed very significantly better than placebo in reducing spasticity and significantly better than placebo in allowing both active and passive limb movements to be carried out. Notable improvement was also seen in scissoring. Side-effects were minimal and responded promptly to dose reduction. The evaluation of drug effects on muscle spasticity and the pharmacodynamics of baclofen are discussed. Recommendations are made regarding dosage of baclogen in childhood.

References

Aug 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·R F JonesJ D Gillies
Jan 1, 1970·Acta Neurologica Scandinavica·E PedersenO Henriksen
Oct 2, 1971·British Medical Journal·P Hudgson, D Weightman

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