PMID: 11906798Mar 22, 2002Paper

A controlled trial of buprenorphine treatment for opium dependence: the first experience from Iran

Drug and Alcohol Dependence
Jamshid Ahmadi

Abstract

To evaluate the effect of a 4 mg/day sublingual dose of buprenorphine in the maintenance treatment of opium dependence in comparison with a 1 mg/day dose over an 18-week treatment period. As a secondary objective, the results were determined concurrently for subjects treated with a 2 mg/day dose. Subjects were assigned randomly to three dosage groups. 330 consecutive (320 men and 10 women) opium addicts who met the DSM-IV criteria for opioid dependence and were seeking treatment. Subjects received a 1, 2 or 4 mg/day dose of buprenorphine and were treated in an outpatient clinic where they also received a weekly 1-hour clinical counseling session. Addiction Severity Index, retention in treatment, and illegal opioid use as determined by random urine testing. The mean age was 37.5 years (SD=11.4, range 19-72). Overall, 194 (58.8%) of the patients completed the 18 week study. Completion rates by dosage groups were 47.3% for the 1 mg group, 58.2% for the 2 mg group and 70.9% for the 4 mg group (chi(2)=12.7, df=2, P=0.0017). The results support the efficacy and safety of buprenorphine for opium addiction and suggest that an adequate dose of buprenorphine would help to increase the success rate.

References

Jan 1, 1991·NIDA Research Monograph·A F KolarJ C Ball
Aug 1, 1990·Drug and Alcohol Dependence·W R LangeR E Johnson
Aug 13, 1987·The New England Journal of Medicine·R G Newman
May 1, 1982·British Journal of Clinical Pharmacology·R E BullinghamR A Moore

❮ Previous
Next ❯

Citations

Dec 23, 2003·Drug and Alcohol Dependence·Bai-Fang X SobelGeorge E Bigelow
May 10, 2003·Drug and Alcohol Dependence·Rolley E JohnsonLeslie Amass
Feb 14, 2007·Experimental and Clinical Psychopharmacology·Stacey C Sigmon
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Oct 27, 2004·Addiction·Stacey C SigmonGeorge E Bigelow
Feb 28, 2006·Addiction·Stacey C SigmonGeorge E Bigelow
Sep 15, 2007·Addiction·Ryan K LanierGeorge E Bigelow
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Afarin Rahimi-MovagharReza Yousefi-Nooraie
Nov 28, 2019·Indian Journal of Psychological Medicine·Preethy KathiresanSiddharth Sarkar
Dec 20, 2007·British Journal of Hospital Medicine·Sanju George, Ed Day
May 3, 2019·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Sai Krishna TikkaK Hari Hara Suchandra
Feb 7, 2014·The Cochrane Database of Systematic Reviews·Richard P MattickMarina Davoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.