A controlled trial of immunotherapy in insect hypersensitivity

The New England Journal of Medicine
K J HuntL M Lichtenstein

Abstract

Insect hypersensitivity is currently treated by immunization using whole-body extracts. We compared this regimen with immunotherapy using insect venoms or placebo in groups of 20 patients matched for history and sensitivity, as judged by venom skin test, histamine release and IgE antibody to venom. After six to 10 weeks of immunization, systemic reactions to stings occurred in seven of 12, seven of 11, and one of 18 patients treated with placebo, whole-body extract, and venom, respectively. Placebo and whole-body extract gave similar results and were significantly less effective than venom immunotherapy (P less than 0.01). The 14 patients with failure of treatment with whole-body extract and placebo were subsequently provided with venom immunotherapy; one reacted to a subsequent sting. We conclude that venom immunotherapy is clinically superior to therapy on whole-body extract or placebo.

References

Jan 1, 1976·The Journal of Allergy and Clinical Immunology·A K SobotkaL M Lichtenstein
Jul 1, 1976·Annals of Internal Medicine·K J HuntL M Lichtenstein
Jan 1, 1978·The Journal of Allergy and Clinical Immunology·K J HuntL M Lichtenstein
Mar 1, 1974·The Journal of Allergy and Clinical Immunology·A K SobotkaL M Lichtenstein
May 30, 1974·The New England Journal of Medicine·L M LichtensteinA K Sobotka
Nov 1, 1973·The Journal of Allergy and Clinical Immunology·P J Torsney
Sep 1, 1972·The Journal of Allergy and Clinical Immunology·G A SettipaneG K Boyd
Apr 1, 1970·Archives of Internal Medicine·H Brown, H S Bernton
Aug 1, 1970·Acta Allergologica·F H Chafee
Aug 24, 1964·JAMA : the Journal of the American Medical Association·B C BROWNM B MOORE
Oct 11, 1963·Science·A W BentonJ D Stewart

❮ Previous
Next ❯

Citations

Feb 12, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·F Ruëff, B Przybilla
Jun 17, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·H OttH F Merk
Jun 28, 2012·Seminars in Immunopathology·Michele Henson, A Wesley Burks
Mar 15, 2002·Current Allergy and Asthma Reports·H Løwenstein, J N Larsen
Apr 2, 2008·Current Allergy and Asthma Reports·David M Lang
Apr 1, 2011·Current Allergy and Asthma Reports·Rafael Firszt, A Wesley Burks
Nov 29, 2012·Current Allergy and Asthma Reports·Emily C McGowan, Sarbjit Saini
Jan 1, 1983·Toxicon : Official Journal of the International Society on Toxinology·C L Wood, D R Hoffman
Jan 1, 1984·Toxicon : Official Journal of the International Society on Toxinology·R E ReismanJ I Wypych
Dec 1, 1980·The Journal of Allergy and Clinical Immunology·R PattersonJ J Pruzansky
Nov 1, 1981·The Journal of Allergy and Clinical Immunology·R L CaseP P VanArsdel
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·D I BernsteinI L Bernstein
Jan 1, 1983·The Journal of Emergency Medicine·W C Lucke, H Thomas
Jan 1, 1995·The Journal of Emergency Medicine·L McDougleF K Hoehler
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Sheldon G Cohen
Mar 9, 2005·The Journal of Allergy and Clinical Immunology·David B K Golden
Apr 1, 1987·The Journal of Allergy and Clinical Immunology·R F LockeyS C Bukantz
Oct 1, 2004·Allergologia et immunopathologia·A Iglesias-CadarsoA Pérez-Pimiento
Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda Cox
Feb 12, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David B K GoldenAnne Kagey-Sobotka
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Feb 8, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arnon Goldberg, Ronit Confino-Cohen
Mar 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Tomaz HafnerMitja Kosnik
Jun 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bret R HaymoreMichael R Nelson
Feb 25, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David B K Golden
Jan 31, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Yael GraifArnon Goldberg
Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eyal OrenDaniel L Hamilos
Dec 22, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·John E Moffitt
Aug 9, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arnaldo E AlessandriniSamuele E Burastero
Apr 24, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Domenico SchiavinoGiampiero Patriarca
Apr 24, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Shelly M HarveyDavid A Khan
Apr 3, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Todd M Hrabak, John P Dice
Aug 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A LitwinJ G Michael
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. FishmanM. Altaras
Nov 16, 1978·The New England Journal of Medicine
Mar 8, 1979·The New England Journal of Medicine·J A Grant
Dec 6, 1990·The New England Journal of Medicine·M D ValentineL M Lichtenstein
Dec 6, 1990·The New England Journal of Medicine·R F Lockey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Annals of Internal Medicine
D B GoldenL M Lichtenstein
The Journal of Allergy and Clinical Immunology
D B GoldenL M Lichtenstein
The Journal of Allergy and Clinical Immunology
L M LichtensteinA K Sobotka
© 2021 Meta ULC. All rights reserved