Insect hypersensitivity is currently treated by immunization using whole-body extracts. We compared this regimen with immunotherapy using insect venoms or placebo in groups of 20 patients matched for history and sensitivity, as judged by venom skin test, histamine release and IgE antibody to venom. After six to 10 weeks of immunization, systemic reactions to stings occurred in seven of 12, seven of 11, and one of 18 patients treated with placebo, whole-body extract, and venom, respectively. Placebo and whole-body extract gave similar results and were significantly less effective than venom immunotherapy (P less than 0.01). The 14 patients with failure of treatment with whole-body extract and placebo were subsequently provided with venom immunotherapy; one reacted to a subsequent sting. We conclude that venom immunotherapy is clinically superior to therapy on whole-body extract or placebo.
Leukocyte histamine release in Hymenoptera-allergic patients. Correlation with skin test reactivity and changes following hyposensitization therapy
Allergy to insect stings. I. Diagnosis of IgE-mediated hymenoptera sensitivity by venom-induced histamine release
Immunotherapy of hay fever with ragweed antigen E: comparisons with whole pollen extract and placebos
Immunologic mechanisms of penicillin allergy. A haptenic model system for the study of allergic diseases of man
Diagnosis and treatment of insect venom allergy. An important allergic issue for the ear, nose and throat specialist
Comparison of the biochemical, immunologic and allergenic properties of vespid venoms collected in early and late summer
Antibodies to purified bee venom proteins and peptides. II. A detailed study of changes in IgE and IgG antibodies to individual bee venom antigens
Immunotherapy with partially purified and standardized animal dander extracts. I. Clinical results from a double-blind study on patients with animal dander asthma
Should routine measurements of serum venom-specific IgG be a standard of practice in patients receiving venom immunotherapy?
Emergency medical treatment of anaphylactic reactions. Project Team of The Resuscitation Council (UK)
Dialyzed venom skin tests for identifying yellow jacket-allergic patients not detected using standard venom
Imported fire ant immunotherapy prescribing patterns in a large health care system during a 17-year period
Flexible approaches in the design of subcutaneous immunotherapy protocols for Hymenoptera venom allergy
Immunologic effects of encapsulated short ragweed extract: a potent new agent for oral immunotherapy
The frequency of phospholipase A2 binding of basophilic granulocytes does not decrease during bee-venom-specific immunotherapy
Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial
Venom immunotherapy modulates interleukin-4 and interferon-gamma messenger RNA expression of peripheral T lymphocytes
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.