PMID: 2121104Oct 1, 1990Paper

A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Clinical and histologic findings

Archives of Dermatology
R D GransteinE P Amento

Abstract

Interferon-gamma (IFN-gamma) suppresses the synthesis of collagen by fibroblasts in vitro and the synthesis of collagen in vivo in animal models. Therefore, recombinant human IFN-gamma was examined for its ability to clinically modify keloids. Subjects were treated by injection of either 0.01 or 0.1 mg of recombinant human IFN-gamma into one lesional site and diluent alone into another lesional site three times per week for 3 weeks. Keloids were measured and photographed before beginning therapy and weekly thereafter. Three days after the final injection, biopsies were performed on treated and control sites. Six of eight subjects who finished the course of treatment demonstrated reduction in size at the treated site with an average reduction in height of 30.4% vs 1.1% for control sites. Lesions treated with recombinant human IFN-gamma demonstrated alterations in both the epidermis and dermis. The epidermis showed thinning of the suprapapillary plates, compact hyperkeratosis, focal or diffuse parakeratosis, exocytosis of lymphocytes, and an increased quantity of mucin. The dermis contained a diminished quantity of thickened collagen bundles and active fibroblasts and an increased number of inflammatory cells and quantity of muci...Continue Reading

Citations

Aug 1, 1996·Burns : Journal of the International Society for Burn Injuries·H A Linares
Jun 26, 2003·The Surgical Clinics of North America·Ginard Henry, Warren L Garner
Nov 19, 2002·Clinics in Dermatology·Edith OrionRonni Wolf
Dec 20, 2002·Clinics in Dermatology·Binnur TüzünYalçin Tüzün
Jun 6, 2003·Journal of Dermatological Science·Toshio HasegawaHideoki Ogawa
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·T J Franklin
Sep 1, 1999·The British Journal of Dermatology·G PrantedaT Grieco
Mar 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E E TredgetA Ghahary
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GhaharyQ Shen
Dec 7, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jianfei WangEdward E Tredget
Jul 4, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jianfei WangEdward E Tredget
Jul 27, 2002·Plastic and Reconstructive Surgery·Thomas A MustoeUNKNOWN International Advisory Panel on Scar Management
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison
Jan 13, 2006·Plastic and Reconstructive Surgery·Steven P DavisonAli Al-Attar
Jun 28, 2006·Plastic and Reconstructive Surgery·George BroughtonChristopher E Attinger
Dec 5, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jennifer A LedonKeyvan Nouri
Jul 1, 1996·International Journal of Dermatology·M M al-Khawajah
Aug 1, 1993·The Journal of Dermatologic Surgery and Oncology·A J Nemeth
Nov 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·D S Greenstein, G S Rogers
Apr 12, 2003·American Journal of Clinical Dermatology·Tina S Alster, Elizabeth L Tanzi
Jul 1, 2010·American Journal of Clinical Dermatology·Brian Berman
Feb 5, 2000·British Journal of Plastic Surgery·P Kloen
Jan 21, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Jan 16, 1999·European Journal of Dermatology : EJD·B Berman, F Flores
Apr 29, 2014·Burns : Journal of the International Society for Burn Injuries·Anna I ArnoMarc G Jeschke
Jul 2, 2010·Nutrition Reviews·Angela C B FerreiraLydia M Ferreira
May 1, 1996·Annals of the Royal College of Surgeons of England·S T O'SullivanT P O'Connor
Jul 14, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·K FroelichR Hagen
Nov 1, 1992·The Journal of Dermatologic Surgery and Oncology·S Q Low, R L Moy
Oct 24, 1998·The International Journal of Biochemistry & Cell Biology·D G Greenhalgh
May 4, 2011·Clinics and Research in Hepatology and Gastroenterology·D Montgomery Bissell
Apr 17, 2001·Pediatric Annals·I C ValenciaL A Schachner
Jun 20, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Peter Donkor
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Alexander G Marneros, Thomas Krieg
Jan 24, 2004·The Journal of Dermatology·Sung-Eun ChangKyung-Jeh Sung
Nov 15, 2013·Clinical & Experimental Ophthalmology·Xiao Yang WangPaul R Healey
Dec 17, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Barbara ShihArdeshir Bayat
Dec 28, 2006·Journal of the American Academy of Dermatology·David I SmithMichael P Heffernan
Jan 25, 2002·Journal of the American Academy of Dermatology·Joseph J ShafferFran Cook-Bolden
Jan 15, 1999·International Journal of Dermatology·D S Hurd, E T Conte
May 23, 2016·Annales de chirurgie plastique et esthétique·C JalouxC Philandrianos

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