A controlled trial of leuprolide with and without flutamide in prostatic carcinoma

The New England Journal of Medicine
E D CrawfordP J Goodman

Abstract

To test the hypothesis that maximal androgen blockade improves the effectiveness of the treatment of prostatic cancer, we conducted a randomized, double-blind trial in patients with disseminated, previously untreated prostate cancer (stage D2). All 603 men received leuprolide, an analogue of gonadotropin-releasing hormone that inhibits the release of gonadotropins, in combination with either placebo or flutamide, a nonsteroidal antiandrogen that inhibits the binding of androgens to the cell nucleus. As compared with the 300 patients receiving leuprolide and placebo, the 303 patients randomly assigned to receive leuprolide and flutamide had a longer progression-free survival (16.5 vs. 13.9 months; P = 0.039) and an increase in the median length of survival (35.6 vs. 28.3 months; P = 0.035). The differences between the treatments were particularly evident for men with minimal disease and good performance status; however, further studies should be conducted in this subgroup. Symptomatic improvement was greatest during the first 12 weeks of the combined androgen blockade, when leuprolide alone often produces a painful flare in the disease. We conclude that in patients with advanced prostate cancer, treatment with leuprolide and flu...Continue Reading

References

Jun 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A EisenbergerM A Friedman
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A EisenbergerM A Friedman
Aug 1, 1987·Endocrine Reviews·G R CunhaY Sugimura
May 1, 1985·The Journal of Urology·J Trachtenberg
Nov 15, 1984·The New England Journal of Medicine·UNKNOWN Leuprolide Study Group
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·J GellerD A Nachtsheim
Apr 1, 1980·Cancer·William W ScottPatrick C Walsh

❮ Previous
Next ❯

Citations

Jul 27, 1999·The Prostate·N J HegartyD S Coffey
Jan 5, 2000·Seminars in Surgical Oncology·M K Brawer
Jan 5, 2000·Seminars in Surgical Oncology·L J Denis, K Griffiths
Oct 12, 2000·The Prostate·A T WeeraratnaJ T Isaacs
Nov 24, 2004·Cancer·Sam S ChangUNKNOWN Society of Urologic Oncology, Shaumberg, Illinois
Jan 1, 1994·The Prostate. Supplement·L Denis
Jan 1, 1995·Seminars in Surgical Oncology·E D CrawfordC A Coltman
Jan 1, 1995·Seminars in Surgical Oncology·D W Newling
Jan 1, 1997·Urological Research·W J Kirkels, J B Rietbergen
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·K Parczyk, M R Schneider
Sep 1, 1993·Digestive Diseases and Sciences·A S RosmanF Paronetto
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·P SagasterH Ludwig
Jan 1, 1997·International Urology and Nephrology·O KayigilA Metin
Jan 1, 1996·Pathology Oncology Research : POR·Kenneth V HonnDavid P Wood

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.