A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity

Bioorganic & Medicinal Chemistry Letters
T NarenderSuman Gupta

Abstract

2',2'-Dimethyl chromeno dihydrochalcones are very rare in nature as plant secondary metabolites. Recently we have reported three such compounds from the plant Crotalaria ramosissima. Chromeno dihydrochalcones contain a 2',2'-dimethyl benzopyran system, which are frequently encountered in many natural products and exhibit a variety of biological activities. We here report the strategy to conveniently synthesize naturally occurring chromeno dihydrochalcones by biogenetic type pyridine or Amberlyst-15 catalyzed chromenylation of dihydrochalcones and in vitro antileishmanial activity of chromeno dihydrochalcones and their intermediates.

Citations

Mar 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zahra SaffariAli Farhangi
Nov 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rawda M OkashaAhmed M El-Agrody
Mar 27, 2010·Chemical Biology & Drug Design·Alireza ForoumadiAbbas Shafiee
May 1, 2019·AMB Express·Carla Janaina Rebouças Marques do RosárioFerdinan Almeida Melo
Nov 24, 2012·Organic & Biomolecular Chemistry·Somayeh AhadiAyoob Bazgir
Aug 21, 2012·Acta Crystallographica. Section E, Structure Reports Online·Shaaban K MohamedMustafa R Albayati
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons

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