A core deficit in Parkinson disease?

Neurología : publicación oficial de la Sociedad Española de Neurología
A Benítez-BurracoF Cuetos

Abstract

Parkinson disease is a neurodegenerative condition involving motor, cognitive, and linguistic deficits. It is important to know why all these different deficits co-occur in the affected people. This paper aims to clarify whether these comorbid deficits result from the selective impairment of a computational primitive, namely, a context-sensitive computational ability according to Chomsky's Hierarchy (a well-established research tool in comparative neuroscience). A total of 15 medicated subjects with Parkinson disease and 15 controls were selected. They were matched in age and education. A battery of tasks was designed to test 3 different domains (motor capacities, cognition, and language) and 2 different computational abilities (context-free and context-sensitive operations). Significant differences between groups were observed only regarding the linguistic task involving context-sensitive computations (correferences). The observed deficits in our patients with Parkinson disease cannot be explained in terms of the selective impairment of one only unspecific, low-level computational process. At the same time, differences between patients and controls are expected to be greater if the former are not medicated. Moreover, we should...Continue Reading

References

Jan 1, 1993·Cognition·J C Sherman, B Lust
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 23, 2003·Brain Research. Cognitive Brain Research·Michiru MakuuchiMorihiro Sugishita
Nov 5, 2003·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·P MariniM Paganini
Jan 17, 2004·Science·W Tecumseh Fitch, Marc D Hauser
Jun 1, 2005·Trends in Cognitive Sciences·Timothy J O'DonnellW Tecumseh Fitch
Nov 29, 2005·Cognition·Moises BetancortCarlos Acuña-Fariña
Jul 11, 2006·Trends in Biochemical Sciences·James F Gusella, Marcy E MacDonald
Oct 24, 2006·Clinical Linguistics & Phonetics·Anne Hesketh
Apr 25, 2007·Human Brain Mapping·Bertram Opitz, Angela D Friederici
Jul 22, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Laura DipietroNeville Hogan
Apr 10, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Anthony J AngwinHelen J Chenery
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jul 9, 2010·Trends in Genetics : TIG·Roberto ToroThomas Bourgeron
Jan 5, 2011·The British Journal of Developmental Psychology·Kerry D Hudson, Emily K Farran
Jan 25, 2012·Journal of Experimental Psychology. Learning, Memory, and Cognition·Anna FedorEörs Szathmáry
Jun 13, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W Tecumseh Fitch, Angela D Friederici
Jan 22, 2013·Topics in Cognitive Science·Jeffrey Heinz, William Idsardi
Feb 16, 2013·Brain Structure & Function·Juan Felipe CardonaAgustín Ibáñez
Oct 1, 2013·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Xiao-Yun BuZhi-Yi He
Sep 6, 2014·Frontiers in Systems Neuroscience·Ahmed A MoustafaHagai Bergman
Mar 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Léon TremblayJean Féger
Apr 9, 2015·Alzheimer Disease and Associated Disorders·David K JohnsonJames E Galvin
Mar 12, 2016·Journal of Communication Disorders·Antonio Benítez-BurracoFernando Cuetos

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