A core outcome set for adult cardiac surgery trials: A consensus study

PloS One
Carina BenstoemA Goetzenich

Abstract

Invasive off- or on-pump cardiac surgery (elective and emergency procedures, excluding transplants are routinely performed to treat complications of ischaemic heart disease. Randomised controlled trials (RCT) evaluate the effectiveness of treatments in the setting of cardiac surgery. However, the impact of RCTs is weakened by heterogeneity in outcome measuring and reporting, which hinders comparison across trials. Core outcome sets (COS, a set of outcomes that should be measured and reported, as a minimum, in clinical trials for a specific clinical field) help reduce this problem. In light of the above, we developed a COS for cardiac surgery effectiveness trials. Potential core outcomes were identified a priori by analysing data on 371 RCTs of 58,253 patients. We reached consensus on core outcomes in an international three-round eDelphi exercise. Outcomes for which at least 60% of the participants chose the response option "no" and less than 20% chose the response option "yes" were excluded. Eighty-six participants from 23 different countries involving adult cardiac patients, cardiac surgeons, anaesthesiologists, nursing staff and researchers contributed to this eDelphi. The panel reached consensus on four core outcomes: 1) Mea...Continue Reading

References

Feb 17, 2010·BMJ : British Medical Journal·Jamie J KirkhamPaula R Williamson
Aug 8, 2012·Trials·Paula R WilliamsonPeter Tugwell
Mar 4, 2014·Journal of Clinical Epidemiology·Maarten BoersPeter Tugwell
Oct 19, 2016·PLoS Medicine·Jamie J KirkhamPaula R Williamson

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Citations

Jul 31, 2018·PloS One·Deborah Ann HallUNKNOWN Core Outcome Measures in Tinnitus International Delphi (COMiT’ID) Research Steering Group
Aug 11, 2020·Current Opinion in Critical Care·Victor D DinglasDale M Needham
May 18, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Emma O'LoneUNKNOWN SONG-HD CVD Consensus Workshop Investigators

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Software Mentioned

OMERACT
COS
eDelphi
COMET
QuestionPro

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