A correlative study of the antiulcer effects of zinc sulphate in stressed rats

European Journal of Pharmacology
C H Cho, C W Ogle

Abstract

The effects on zinc sulphate pretreatment of rats on stress-induced gastric ulcers and on changes in mast cell counts were studied and correlated with changes in gastric mucosal microcirculation. The effects on zinc sulphate on blood pressure responses and on growth were also examined. Stress (2 h restraint at 4 degrees C) produced marked glandular mucosal ulceration, lowered the stomach wall mast cell counts and increased the microcirculatory blood volume in the superficial glandular mucosa. Zinc sulphate (22, 44 or 88 mg/kg; injected i.p. 48 h before stress) reversed all these changes in a dose-related manner. Blood pressure responses to i.v. acetylcholine, adrenaline or histamine were unaffected and growth of the rats as observed for 7 days after injection was not impaired. On the basis of these findings the mechanism of the antiulcer action of zinc sulphate is the following: inhibition of the stress-induced release of vasoactive agents from gastric mast cells and thus prevention of the subsequent microciculatory changes known to produce mucosal ulceration. Interference with vascular responses through direct blockade or toxicity is unlikely.

References

Jan 1, 1975·European Journal of Pharmacology·S Dai, C W Ogle
Jun 15, 1977·European Journal of Pharmacology·C H Cho, C W Ogle
Sep 1, 1975·European Journal of Pharmacology·S DaiC H Lo
Apr 1, 1974·European Journal of Pharmacology·S Dai, C W Ogle
Jan 15, 1970·Experientia·R Keller, E Sorkin
Apr 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·E C Senay, R J Levine

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Citations

Aug 1, 1988·Biological Trace Element Research·F BarbarinoI Marinescu
May 15, 1979·European Journal of Pharmacology·C W Ogle, H K Lau
Feb 1, 1980·European Journal of Pharmacology·C J PfeifferD Saltman
Jun 15, 1984·European Journal of Pharmacology·M M HoC W Ogle
Feb 26, 1985·European Journal of Pharmacology·J V EspluguesJ Esplugues
Jun 7, 1985·European Journal of Pharmacology·C W Ogle, C H Cho
Jun 19, 1985·European Journal of Pharmacology·C W OgleM W Koo
Jan 29, 1986·European Journal of Pharmacology·M W KooC W Ogle
Jan 3, 1991·European Journal of Pharmacology·W M al-MashhadaniH M al-Zahawi
Jul 1, 1980·Pharmacology, Biochemistry, and Behavior·C H ChoA Cheema
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·M W KooC W Ogle
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·C H ChoC W Ogle
Jul 1, 1989·Pharmacology, Biochemistry, and Behavior·M W KooC W Ogle
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·B S QiuC W Ogle
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·W P Paré, G B Glavin
May 15, 1996·Environmental Toxicology and Pharmacology·D WongC H Cho
Jun 5, 2002·European Journal of Pharmacology·Ho H LukChi H Cho
May 1, 1989·Journal of Gastroenterology and Hepatology·C H Cho, C J Pfeiffer
Sep 1, 1995·Journal of Gastroenterology and Hepatology·D Wong, C W Ogle
Jan 1, 1997·Journal of Gastroenterology and Hepatology·B S QiuC H Cho
Jan 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S NakajimaT Bamba
Apr 1, 1992·The Journal of Pharmacy and Pharmacology·C H ChoS K Lam
Jun 1, 1992·The Journal of Pharmacy and Pharmacology·K D Rainsford, M W Whitehouse
Dec 24, 2013·Journal of Molecular Endocrinology·Lin XiaoOneel Patel
Oct 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G EscolarO Bulbena
Oct 22, 2016·Journal of Ethnopharmacology·Pareeya BaiubonChaiyong Rujjanawate
Sep 1, 1987·British Journal of Pharmacology·C H ChoE L Sevilla
May 1, 1985·Pflügers Archiv : European journal of physiology·O PompeianoU C Srivastava
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·S UekiE Tagashira
Apr 1, 1992·Scandinavian Journal of Gastroenterology·C H ChoC W Ogle
Jul 1, 1990·The Journal of Pharmacy and Pharmacology·C H Cho, C W Ogle
Jan 1, 1988·The Journal of Pharmacy and Pharmacology·J M LlorisJ Esplugues
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peerachit TonchaiyaphumPuongtip Kunanusorn

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