A corticotropin-releasing factor system expressed in the cochlea modulates hearing sensitivity and protects against noise-induced hearing loss.

Neurobiology of Disease
Christine E GrahamD E Vetter

Abstract

Noise-induced hearing loss is a highly prevalent occupational injury, yet little is known concerning the signals controlling normal cochlear sensitivity and susceptibility to noise-induced trauma. While the corticotropin-releasing factor (CRF) system is involved in activation of the classic hypothalamic-pituitary-adrenal axis, it is also involved in local physiological responses to stress in many tissues, and is expressed in the inner ear. We demonstrate that mice lacking the CRF receptor CRFR2 exhibit a significantly lower auditory threshold than wild type mice, but this gain of function comes at the price of increased susceptibility to acoustic trauma. We further demonstrate that glutamatergic transmission, purinergic signaling, and activation of Akt (PKB) pathways within the cochlea are misregulated, which may underlie the enhanced sensitivity and trauma susceptibility observed in CRFR2(-/-) mice. Our data suggest that CRFR2 constitutively modulates hearing sensitivity under normal conditions, and thereby provides protection against noise-induced hearing loss.

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Citations

Jan 21, 2011·Expert Opinion on Emerging Drugs·Naoki Oishi, Jochen Schacht
Jan 20, 2017·Neural Plasticity·Xiaolong FuJiangang Gao
Sep 13, 2018·Reviews in the Neurosciences·Catherine Pérez-ValenzuelaAlexies Dagnino-Subiabre
May 26, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Trung N LeBrian Westerberg
Jul 9, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ian A BouyoucosW Gary Anderson

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