PMID: 9540935Apr 16, 1998Paper

A cost-effectiveness analysis of prenatal carrier screening for cystic fibrosis

Obstetrics and Gynecology
Anthony M VintzileosT Beazoglou

Abstract

To examine the cost-effectiveness of prenatal carrier screening for cystic fibrosis. A cost-benefit equation was developed that was based on the hypothesis that the cost of prenatal diagnosis required to diagnose and prevent one case of cystic fibrosis should be equal to or less than the lifetime cost generated from the birth of a neonate with cystic fibrosis. The formula was adjusted because a woman's positive or negative carrier status remains unchanged, thus eliminating the need for testing in subsequent pregnancies. The formula was manipulated to identify the optimal cost per screening test, as well as the net cost savings per prenatally diagnosed case of cystic fibrosis for various racial or ethnic groups. Sensitivity analyses included some key assumptions regarding the cost per screening test ($50-150), patient screening acceptance rates (25-100%), and therapeutic abortion rates (50-100%). Assuming therapeutic abortion rates of 50-100%, the net savings per prenatally diagnosed case of cystic fibrosis are $58,369-$382,369 among whites. Given the previously reported patient screening acceptance rates of 50-78%, the overall annual cost savings in the United States for whites are $161-251 million. However, the screening progr...Continue Reading

References

Jul 25, 1992·Lancet·M E MennieD J Brock
Dec 1, 1996·Clinical Obstetrics and Gynecology·T Doksum, B A Bernhardt

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Citations

Mar 25, 2005·Journal of Genetic Counseling·Elinor Langfelder-SchwindUNKNOWN National Society of Genetic Counselors Subcommittee on Cystic Fibrosis Carrier Testing
Jun 10, 2005·Genetic Testing·Francis A M Weijers-PoppelaarsLeo P Ten Kate
May 20, 2000·The Journal of Perinatal & Neonatal Nursing·S A Demsey
Sep 20, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Emma WarrenJane Hall
Nov 17, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Wayne W GrodyMichael S Watson
Feb 5, 2005·Gynecologic and Obstetric Investigation·Aaron B Caughey
Jun 16, 2006·Applied Health Economics and Health Policy·James Jarrett, Miranda Mugford
Jul 3, 2010·Reproductive Biomedicine Online·I Tur-KaspaY Verlinsky
Aug 31, 2007·Health Policy·Muralikrishnan RadhakrishnanJohn Massie
Jul 11, 2002·Obstetrics and Gynecology Clinics of North America·Wendy L KinzlerAnthony M Vintzileos
Oct 4, 2003·American Journal of Obstetrics and Gynecology·Nora M Doyle, Michael O Gardner
Oct 28, 2004·American Journal of Obstetrics and Gynecology·Anthony M Vintzileos, Tryfon Beazoglou
Mar 21, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Philippa BriceMiranda Mugford
Nov 19, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·L NshimyumukizaD Reinharz
Jun 27, 2015·The Spine Journal : Official Journal of the North American Spine Society·Steven J McAnanySheeraz A Qureshi
Nov 4, 2000·The Medical Journal of Australia·I FindlayM H Parker

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