A cost-effectiveness analysis of propofol versus midazolam for procedural sedation in the emergency department

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Corinne Michèle HohlAslam Hayat Anis

Abstract

To determine the incremental cost-effectiveness of using propofol versus midazolam for procedural sedation (PS) in adults in the emergency department (ED). The authors conducted a cost-effectiveness analysis from the perspective of the health care provider. The primary outcome was the incremental cost (or savings) to achieve one additional successful sedation with propofol compared to midazolam. A decision model was developed in which the clinical effectiveness and cost of a PS strategy using either agent was estimated. The authors derived estimates of clinical effectiveness and risk of adverse events (AEs) from a systematic review. The cost of each clinical outcome was determined by incorporating the baseline cost of the ED visit, the cost of the drug, the cost of labor of physicians and nurses, the cost and probability of an AE, and the cost and probability of a PS failure. A standard meta-analytic technique was used to calculate the weighted mean difference in recovery times and obtain mean drug doses from patient-level data from a randomized controlled trial. Probabilistic sensitivity analyses were conducted to examine the uncertainty around the estimated incremental cost-effectiveness ratio using Monte Carlo simulation. Ch...Continue Reading

References

Dec 27, 1979·The New England Journal of Medicine·T W Moloney, D E Rogers
Sep 6, 1985·JAMA : the Journal of the American Medical Association·M Angell
Jun 22, 1974·British Medical Journal·M A RamsayR Goodwin
Feb 9, 1999·The Journal of Emergency Medicine·G InnesA Drummond
Nov 25, 2003·Annals of Emergency Medicine·Blanca Coll-VinentMiquel Sánchez
Jul 20, 2004·The American Journal of Emergency Medicine·Lance BrownJonathan W Crabb
Jan 7, 2005·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·David McD TaylorPeter A Cameron
Mar 15, 2005·The American Journal of Emergency Medicine·Bradley W FrazeeMark Baire
May 11, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Steve Morgan
May 18, 2005·Annals of Internal Medicine·Thomas Bodenheimer
May 26, 2005·The American Journal of Emergency Medicine·Joel S HolgerStephanie Haugen
Mar 30, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Mine ParlakEmel Sagiroglu
Dec 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Kenneth C ThomasAslam Anis
Mar 6, 2007·PharmacoEconomics·Pierre-Yves CrémieuxPatrick Petit
Jan 24, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Corinne Michèle HohlAslam Hayat Anis

❮ Previous
Next ❯

Citations

Feb 17, 2010·International Journal of Emergency Medicine·P W HodkinsonL A Wallis
May 10, 2013·Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association·Joshua C ReynoldsJon M Hirshon
Mar 24, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·V Bounes, UNKNOWN groupe d’experts Sfar-SFMU
Mar 1, 2011·Annals of Emergency Medicine·Corinne M HohlBoris Sobolev
Oct 16, 2010·The American Journal of Emergency Medicine·Jaime BawdenBrian H Rowe
Jan 24, 2008·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Alan E Jones
Jan 12, 2017·The American Journal of Emergency Medicine·Heleen LameijerEwoud Ter Avest
Nov 19, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael C ThomasAsad E Patanwala
Apr 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Gary Andolfatto, Elaine Willman
Jul 24, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Asad E PatanwalaRichard Thomas
Mar 29, 2014·Paediatric Anaesthesia·Finn L S CoulterBrian J Anderson
Feb 6, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Graham Roche-NagleDheeraj K Rajan
Dec 27, 2019·The Korean Journal of Internal Medicine·Geun Joo ChoiHyun Kang
Mar 2, 2017·World Journal of Gastroenterology : WJG·Eun Hyo JinHyun Chae Jung
Aug 11, 2017·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Lauren F LakerRobert L Wears

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
Corinne Michèle HohlAslam Hayat Anis
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
A SacchettiReva Dubin
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
John H BurtonHenry C Thode
The American Journal of Emergency Medicine
Joel S HolgerStephanie Haugen
© 2021 Meta ULC. All rights reserved