PMID: 9544411Apr 17, 1998Paper

A cost-utility analysis comparing omeprazole with ranitidine in the maintenance therapy of peptic esophageal stricture

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
J M StalR P Reynolds

Abstract

Recent studies have suggested that patients receiving omeprazole for prophylaxis against peptic esophageal stricture recurrence have less dysphagia and require fewer repeat dilations than patients receiving ranitidine. To estimate the incremental utility gain and associated incremental cost of omeprazole compared with those of ranitidine for the maintenance therapy of patients with peptic stricture who required esophageal dilation. Decision analysis using SMLTREE software was used to compare the incremental cost-utility of omeprazole 20 mg once daily with that of ranitidine 150 mg bid for one year. Variables were estimated from the literature, hospital data, and utility analyses involving patients with peptic stricture and health professionals. The primary outcome measure was cost per quality-adjusted life-years (QALYs) gained. The incremental cost of omeprazole compared with that of ranitidine was $556 per patient treated. The incremental utility gain of omeprazole was 0.0112 QALYs. Overall, the incremental cost:utility ratio of omeprazole in the maintenance therapy of patients with peptic stricture was $49,600 per QALY gained. A sensitivity analysis revealed that the estimates with the greatest impact on the cost:utility rati...Continue Reading

Citations

May 29, 2004·European Journal of Gastroenterology & Hepatology·Paul Moayyedi, James Mason
Jun 24, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Sergio Angel MazzadiJuan Carlos Chiocca
Jan 11, 2019·Clinical Medicine Insights. Gastroenterology·Tom RichardsonSayantan Bhattacharya
Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S J WalkerN Birbeck
Dec 22, 1999·The American Journal of Gastroenterology·R M DettmerP H Green
Jan 25, 2003·Critical Care Medicine·Michael T Coughlin, Derek C Angus
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·N VakilK Bergenheim
Dec 13, 2005·Drugs·Fernando Carballo
Jul 9, 2004·Current Treatment Options in Gastroenterology·Dawn D. F. Ferguson, Kenneth R. DeVault

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