A cost-utility analysis of ingenol mebutate gel for the treatment of actinic keratosis: a Scottish perspective

The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care
Keith TolleyHelen Smethurst

Abstract

Actinic keratosis (AK) is a UV-induced, pre-malignant skin condition that is common in adults over 60 years of age with fair skin in Scotland. The most commonly prescribed first-line treatment for AK in Scotland is currently diclofenac gel (3 %). Ingenol mebutate gel is a recently developed topical therapy available in two strengths for the treatment of AK lesions on the face and scalp (150 mcg/g once daily for 3 consecutive days) or trunk and extremities (500 mcg/g once daily for 2 consecutive days). To compare the cost-effectiveness of two strengths of ingenol mebutate gel developed to treat AK lesions on the face and scalp (150 mcg/g once daily for 3 consecutive days) or trunk and extremities (500 mcg/g once daily for 2 consecutive days) with other first-line AK therapies including diclofenac gel, 5-FU, 5-FU/salicylic acid, and cryotherapy for the first-line treatment of AK in adult patients, from the perspective of the National Health Service (NHS) in Scotland. A cost-utility analysis was conducted using a decision-tree approach to calculate the costs and benefits of different treatment strategies for AK on the face and scalp or trunk and limbs over a 12-month time horizon. Data on the relative efficacy of treatments were o...Continue Reading

References

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Citations

Nov 19, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·W G Philipp-DormstonUNKNOWN NMSC-QoL Study Group
Oct 28, 2016·PharmacoEconomics·Spencer M ValeSteven R Feldman
Jun 6, 2017·International Journal of Immunopathology and Pharmacology·Keith TolleyLasse Ryttig
Feb 16, 2019·Mediators of Inflammation·Vlad Mihai VoiculescuConstantin Caruntu

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