A cost-utility analysis of pregabalin in the management of peripheral neuropathic pain

Acta Clinica Belgica
L AnnemansS Marbaix

Abstract

To assess the cost per QALY (quality-adjusted life years) of pregabalin in the management of peripheral neuropathic pain. We compared pregabalin on top of "usual care" with "usual care" alone. In this study, usual care was defined as a mix of drug therapies, excluding anti-epileptic drugs (AEDs), because the latter represented only 9% of current use, and clinical evidence of pregabalin was demonstrated versus usual care without anti-epileptic drugs. A Markov model was developed to simulate the evolution of a patient cohort over 1 year, and applied cycles of 4 weeks. During each cycle, patients remained in 1 out of 4 possible states: severe, moderate or mild pain, and therapy withdrawal. The health care payers perspective was taken into account. Clinical data were obtained from a trial comparing usual care plus placebo to usual care plus pregabalin, at either 150, 300, or 300/600 mg/day (the latter depending on clearance of creatinin). Resulting effects on pain were transformed into transition-probabilities between different pain levels. Cost and SF36 utility data of pain levels were obtained from a 1-month observational study in 88 patients. Usual care resulted in a yearly cost of Euros 6,200 compared to Euros 5,984 for an all ...Continue Reading

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Citations

Jun 21, 2012·Journal of Medical Economics·Matthew PrettyjohnsJan-Rickard Norrefalk
Oct 25, 2011·Journal of Medical Economics·Jason GordonZahava Gabriel
Jan 17, 2014·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Tomoko TetsunagaTomonori Tetsunaga
May 13, 2014·Pain Practice : the Official Journal of World Institute of Pain·Lindsay ParkerJoaquin Mould
Jan 19, 2013·The Clinical Journal of Pain·Concepción PérezJavier Rejas
Jan 15, 2019·PharmacoEconomics·Natalia Ruiz-NegrónBrandon K Bellows
Apr 5, 2019·Cannabis and Cannabinoid Research·Griffin A TyreeDavid J Grelotti
Feb 15, 2021·Value in Health Regional Issues·Emma GrayShuu-Jiun Wang

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