A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand.

BMC Health Services Research
Pattara LeelahavarongYot Teerawattananon

Abstract

Hematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients. The treatment, however, is very costly, particularly in the context of low and middle income countries, and no studies have been carried out to explore its economic justifiability. This study aimed to estimate the cost-utility of HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for severe thalassemia in Thailand, and to investigate the affordability of HSCT using a budget impact analysis. A Markov model was used to estimate the relevant costs and health outcomes over the patients' lifetimes taking a societal perspective as recommended by Thailand's health technology assessment guidelines. All future costs and outcomes were discounted at a rate of 3% per annum. Primary outcomes of interest were lifetime costs, quality adjusted life years (QALYs) gained, and the incremental cost-effectiveness ratio (ICER) in Thai baht (THB) per QALY gained. Compared to BT-ICT, the incremental cost-effectiveness ratio increased with patient age from 80,700 to 183,000 THB per QALY gained for related HSCT and 209,000 to 953,000 THB per QALY gained for unrelated HSCT among patients aged 1 to 15 yea...Continue Reading

References

Mar 24, 1994·The New England Journal of Medicine·J O Armitage
Sep 21, 2000·British Journal of Haematology·S ChiodiA Bacigalupo
Jan 25, 2003·British Journal of Haematology·Sarah E LawsonPhilip J Darbyshire
Feb 3, 2004·American Journal of Infection Control·Judith Morrison, UNKNOWN Health Canada, Nosocomial and Occupational Infections Section
Dec 1, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Mehran KarimiPiero C Giordano
Dec 13, 2005·Annals of the New York Academy of Sciences·Javid GazievGuido Lucarelli
Feb 24, 2006·Health Economics·Mark J SculpherChris McCabe
Jun 2, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Suradej HongengSaengsuree Jootar
Jan 31, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Yot TeerawattananonViroj Tangcharoensathien
Feb 27, 2007·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Michelle H Biros, UNKNOWN Society for Academic Emergency Medicine
Aug 4, 2007·American Journal of Hematology·Suradej HongengSurapol Issaragisil
Nov 1, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Richard H OsbornePhoebe Joy Ho
Nov 28, 2007·Blood Reviews·Guido Lucarelli, Javid Gaziev
May 23, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Vijj KasemsupRonald S Hadsall
Jun 19, 2008·Bone Marrow Transplantation·D K L CheukG C F Chan
Aug 5, 2009·Antimicrobial Agents and Chemotherapy·Elizabeth C WeissMark S Smeltzer
Feb 26, 2010·BMC Blood Disorders·Montarat ThavorncharoensapBang-On Ubol
Mar 10, 2011·The International Journal of Pharmacy Practice·Arthorn RiewpaiboonPiyanuch Piyauthakit
Feb 15, 2012·Asia-Pacific Journal of Public Health·Yupin JopangFrank Peter Schelp

❮ Previous
Next ❯

Citations

Mar 20, 2013·Haematologica·Alois GratwohlUNKNOWN Worldwide Network of Blood and Marrow Transplantation (WBMT)
Aug 3, 2012·Journal of Health Organization and Management·Sripen TantivessYot Teerawattananon
Apr 5, 2016·Hematology/oncology Clinics of North America·Suthat Fucharoen, David J Weatherall
Jun 16, 2012·Blood·Nandita KheraStephanie J Lee
Sep 8, 2020·Bone Marrow Transplantation·Lawrence FaulknerUNKNOWN Pediatric Diseases Working Party of the European Blood and Marrow Transplantation Group
Oct 29, 2020·Pediatric Transplantation·Venkateswaran Vellaichamy SwaminathanRevathi Raj
Apr 21, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M Joseph JohnShankar Prinja

❮ Previous
Next ❯

Software Mentioned

Excel

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.