A coumarin analogue NFA from endophytic Aspergillus fumigatus improves drought resistance in rice as an antioxidant

BMC Microbiology
Wanggege QinShiping Liu

Abstract

Drought and its resulting oxidative damage are the major yield limiting factors for crops in arid and semi-arid regions. Recent studies have found that endophytic fungi coexisting in plants can alleviate biotic or abiotic damage to plant growth and development. In order to screen for the endophytes associated with drought stress, 12 strains of endophytic fungi with high antioxidant activity isolated from riparian plants Myricaria laxiflora were evaluated for their effects in rice by the crude extracts. Of the 12 endophytic fungi, Aspergillus fumigatus SG-17 functioned most effectively, with the crude extract exhibiting relatively higher antioxidant capacity both in vivo and in vitro. The subsequent MS and NMR analysis showed that the primary substance responsible for the antioxidant activity in the extract was (Z)-N-(4-hydroxystyryl) formamide (NFA), an analogue of coumarin. Enzyme activity assay in nerve cells SH-SY5Y showed that NFA could maintain the membrane integrity and regulate the antioxidase activity under oxidative stress. In rice suffering drought stress, NFA effectively alleviated the harm by regulating the contents of NADPH oxidases, antioxidants and heat shock proteins, all of which are closely related with the re...Continue Reading

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Citations

Jun 6, 2020·Frontiers in Bioengineering and Biotechnology·Ayomide Emmanuel Fadiji, Olubukola Oluranti Babalola
Jan 29, 2021·Microbiological Research·Sravanthi Goud Burragoni, Junhyun Jeon
Apr 20, 2021·Archiv der Pharmazie·Fatma A RagabYassin M Nissan
Dec 4, 2021·Plant Molecular Biology·Showkat Ahmad GanieAlessandra Devoto

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Methods Mentioned

BETA
MDA
nuclear magnetic resonance
NMR
GTPase

Software Mentioned

SPSS

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Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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