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A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth

Biochemical and Biophysical Research Communications

Dec 4, 2019

Tomohiro YoshidaCostas A Lyssiotis

Abstract

Metabolic programs are rewired in cancer cells to support survival and tumor growth. Among these, recent studies have demonstrated that glutamate-oxaloacetate transaminase 1 (GOT1) plays key roles in maintaining redox homeostasis and proliferation of pancreatic ductal adenocarcinomas (P...read more

Mentioned in this Paper

Study
GABRR3
Pancreatic Ductal Adenocarcinoma
Kynurenine
Pancreatic Carcinoma
Regulation of Redox Homeostasis
Inhibitors
Inhibition of Growth
Cell Proliferation
Site
27
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A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth

Biochemical and Biophysical Research Communications

Dec 4, 2019

Tomohiro YoshidaCostas A Lyssiotis

PMID: 31787239

DOI: 10.1016/j.bbrc.2019.11.130

Abstract

Metabolic programs are rewired in cancer cells to support survival and tumor growth. Among these, recent studies have demonstrated that glutamate-oxaloacetate transaminase 1 (GOT1) plays key roles in maintaining redox homeostasis and proliferation of pancreatic ductal adenocarcinomas (P...read more

Mentioned in this Paper

Study
GABRR3
Pancreatic Ductal Adenocarcinoma
Kynurenine
Pancreatic Carcinoma
Regulation of Redox Homeostasis
Inhibitors
Inhibition of Growth
Cell Proliferation
Site
27

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