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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Cell Reports

Oct 21, 2016

Konstantinos TzelepisKosuke Yusa

Abstract

Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify additional therapeutic targets in AML, we optimize a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) scree...read more

Mentioned in this Paper

Entire Anterior Leaflet of Mitral Valve
Genome-Wide Association Study
Drug Development
Study
EEF1A1 gene
Pathogenic Aspects
Hoxa10
FLT3
Histone antigen
Ltbr
34
7
3
596
2
Paper Details
References
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  • References48
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A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Cell Reports

Oct 21, 2016

Konstantinos TzelepisKosuke Yusa

PMID: 27760321

DOI: 10.1016/j.celrep.2016.09.079

Abstract

Acute myeloid leukemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify additional therapeutic targets in AML, we optimize a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) scree...read more

Mentioned in this Paper

Entire Anterior Leaflet of Mitral Valve
Genome-Wide Association Study
Drug Development
Study
EEF1A1 gene
Pathogenic Aspects
Hoxa10
FLT3
Histone antigen
Ltbr
34
7
3
596
2

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Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Progress on the studies of association between clustered regularly interspaced short palindromic repeat and antibiotic resistance

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Paper Details
References
  • References48
  • Citations48
12345
  • References48
  • Citations48
12345

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