Feb 1, 2003

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

Current Drug Targets
Debomoy K LahiriLon S Schneider

Abstract

Alzheimer's disease (AD), a progressive, degenerative disorder of the brain, is believed to be the most common cause of dementia amongst the elderly. AD is characterized by the presence of amyloid deposits and neurofibrillary tangles in the brain of afflicted individuals. AD is associated with a loss of the presynaptic markers of the cholinergic system in the brain areas related to memory and learning. AD appears to have a heterogeneous etiology with a large percentage termed sporadic AD arising from unknown causes and a smaller fraction of early onset familial AD (FAD) caused by mutations in one of several genes, such as the beta-amyloid precursor protein (APP) and presenilins (PS1, PS2). These proteins along with tau, secretases, such as beta-amyloid cleaving enzyme (BACE), and apolipoprotein E play important roles in the pathology of AD. On therapeutic fronts, there is significant research underway in the development of new inhibitors for BACE, PS-1 and gamma-secretase as targets for treatment of AD. There is also a remarkable advancement in understanding the function of cholinesterase (ChE) in the brain and the use of ChE-inhibitors in AD. A new generation of acetyl- and butyryl cholinesterase inhibitors is being studied an...Continue Reading

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Mentioned in this Paper

Drug Development
Presenilins
Familial Alzheimer Disease (FAD)
Drug Delivery Systems
APP protein, human
Neurofibrillary Degeneration (Morphologic Abnormality)
Presenilin-1
Anti-Inflammatory Agents
Amyloid Beta Precursor Protein Measurement
Brain

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