A critical appraisal of point-of-care coagulation testing in critically ill patients

Journal of Thrombosis and Haemostasis : JTH
M Levi, B J Hunt

Abstract

Derangement of the coagulation system is a common phenomenon in critically ill patients, who may present with severe bleeding and/or conditions associated with a prothrombotic state. Monitoring of this coagulopathy can be performed with conventional coagulation assays; however, point-of-care tests have become increasingly attractive, because not only do they yield a more rapid result than clinical laboratory testing, but they may also provide a more complete picture of the condition of the hemostatic system. There are many potential areas of study and applications of point-of-care hemostatic testing in critical care, including patients who present with massive blood loss, patients with a hypercoagulable state (such as in disseminated intravascular coagulation), and monitoring of antiplatelet treatment for acute arterial thrombosis, mostly acute coronary syndromes. However, the limitations of near-patient hemostatic testing has not been fully appreciated, and are discussed here. The currently available evidence indicates that point-of-care tests may be applied to guide appropriate blood product transfusion and the use of hemostatic agents to correct the hemostatic defect or to ameliorate antithrombotic treatment. Disappointingly...Continue Reading

References

May 16, 1998·Journal of the American College of Surgeons·J A AcostaD B Hoyt
Apr 26, 2000·Anesthesiology·C W Whitten, P E Greilich
Jul 13, 2000·Critical Care Medicine·S VanderschuerenH Bobbaers
Jun 19, 2003·The Journal of Trauma·Karim BrohiTimothy Coats
Aug 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Marcel Levi, Steven M Opal
Oct 3, 2006·British Journal of Haematology·Peter W CollinsGeorge P Findlay
Aug 1, 2008·Expert Review of Cardiovascular Therapy·Marcel Levi
Oct 29, 2008·Seminars in Thrombosis and Hemostasis·Carl-Erik Dempfle, Martin Borggrefe
Feb 14, 2009·Seminars in Thrombosis and Hemostasis·Emmanuel J Favaloro
Apr 1, 2009·Critical Care : the Official Journal of the Critical Care Forum·Fritz DaudelStephan M Jakob
Jan 7, 2010·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Pär I JohanssonKurt Espersen
Feb 25, 2010·JAMA : the Journal of the American Medical Association·Nicoline J BreetJurriën M ten Berg
Nov 3, 2010·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Rajbabu Pakala, Ron Waksman
Dec 24, 2011·Current Opinion in Anaesthesiology·Pär I Johansson
Jul 11, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Pär I JohanssonSisse R Ostrowski
Aug 1, 2012·The Journal of Trauma and Acute Care Surgery·Bryan A CottonNena Matijevic
Nov 28, 2012·Journal of Thrombosis and Haemostasis : JTH·I RazaK Brohi
Jan 29, 2013·Anesthesiology Clinics·Oliver M Theusinger, Jerrold H Levy
Oct 1, 2013·Transfusion Medicine Reviews·Daniel Bolliger, Kenichi A Tanaka
Oct 10, 2013·Journal of Cardiothoracic and Vascular Anesthesia·David FaraoniOliver M Theusinger
Dec 18, 2013·International Journal of Obstetric Anesthesia·O KarlssonM Hellgren
Jan 11, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas EllerIngvild Birschmann
Feb 12, 2014·Critical Care : the Official Journal of the Critical Care Forum·Marcella C MüllerNicole P Juffermans
Feb 28, 2014·The New England Journal of Medicine·Beverley J Hunt
Apr 23, 2014·International Journal of Laboratory Hematology·M Levi
May 30, 2014·The New England Journal of Medicine·Beverley J Hunt
Dec 3, 2014·Anaesthesia·A Cap, B J Hunt
Dec 30, 2014·Internal and Emergency Medicine·Marcel Levi, Suthesh Sivapalaratnam
Mar 15, 2015·Blood·Sue Pavord, Helena Maybury

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Citations

Feb 26, 2016·Abdominal Radiology·Marc KohliKumar Sandrasegaran
Mar 24, 2017·The Journal of Trauma and Acute Care Surgery·Michael A MeledeoAndrew P Cap
Jun 9, 2018·Journal of Thrombosis and Haemostasis : JTH·D D C A HenriquezJ G van der Bom
Jul 13, 2018·Expert Review of Hematology·Marcel Levi, Suthesh Sivapalaratnam
Sep 12, 2018·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hamsini YagneswarKelly Tart
Jul 15, 2018·Journal of Thrombosis and Haemostasis : JTH·D MajiM A Suster
Jun 3, 2016·Nature Reviews. Disease Primers·Satoshi GandoCheng-Hock Toh
Mar 1, 2020·Journal of Thrombosis and Haemostasis : JTH·Hunter B MooreUNKNOWN Subcommittees on Fibrinolysis, Disseminated Intravascular Coagulation, and Perioperative and Critical Care Thrombosis and He
Mar 29, 2019·Critical Care : the Official Journal of the Critical Care Forum·Donat R SpahnRolf Rossaint
Oct 12, 2018·European Journal of Anaesthesiology·Claire PailleretCharles M Samama
Sep 4, 2020·Journal of Thrombosis and Haemostasis : JTH·Jecko ThachilJerrold H Levy
Sep 28, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Pavel LukasTomas Vymazal
Feb 22, 2017·Intensive Care Medicine·Marcel Levi, Marcus J Schultz
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heta Jigar PanchalLeanne F Harris
Aug 13, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Bernd FroesslerRajvinder Singh
Oct 14, 2020·The Journal of Trauma and Acute Care Surgery·Mark WalshDietmar Fries
Jan 26, 2021·Frontiers in Pediatrics·Alison B Nair, Robert I Parker
Apr 3, 2021·Analytical and Bioanalytical Chemistry·Daishen LuoDamir B Khismatullin
Sep 1, 2019·Current Opinion in Biomedical Engineering·Gregory L DamhorstWilbur A Lam

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