A Critical Appraisal of the Evolution of N-Nitrosoureas as Anticancer Drugs

Apr 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R BouvengJ Müntzing

Synthesis of chlorozotocin, the 2-chloroethyl analog of the anticancer antibiotic streptozotocin

Jan 1, 1975·Journal of Medicinal Chemistry·T P JohnstonJ A Montgomery

The metabolic fate and elimination of streptozotocin

Jan 1, 1975·Biochemical Society Transactions·E H KarunanayakeG Mellows

Variants in the sugar component of streptozotocin

Jan 29, 1975·Helvetica Chimica Acta·N GassmannE Hardegger

Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with streptozotocin, its analogs, and N-methyl-N'-nitro-N-nitrosoguanidine

May 1, 1976·Chemico-biological Interactions·B K BhuyanC Heidelberger

Studies on streptozotocin diabetes

Jul 1, 1976·Diabetes·O P GandaA A Like

Alkyl streptozotocin analogues with improved biological activities

Jul 1, 1976·Journal of Medicinal Chemistry·M IwasakiY Nagamatsu

Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential

Aug 30, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·G EisenbrandW J Zeller

Analogs and conversion products of streptozotocin

Nov 1, 1976·The Journal of Antibiotics·P F WileyV H Wiley

Comparison of the properties of metabolites of CCNU

Dec 15, 1977·Biochemical Pharmacology·G P WheelerJ A Montgomery

Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, streptozotocin and N-methyl-N'-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays

Aug 1, 1978·Mutation Research·G FicsorS J Stewart

L-Chlorozotocin.

May 1, 1979·Journal of Medicinal Chemistry·T P JohnstonD S Murinson

Examination of four newly synthesized 2-chloroethylnitrosoureas in comparison with BCNU, CCNU, MeCCNU, chlorozotocin and hydroxyethyl-CNU in preterminal rat leukemia L 5222.

Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·W J ZellerH H Fiebig

Carcinogenic activity in Sprague-Dawley rats of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-gluco-pyranose (chlorozotocin).

Dec 1, 1979·Cancer Letters·M HabsD Schmähl

Microadioautographic study of the distribution and uptake of [14C] streptozotocin in rat tissue.

Jan 1, 1975·Biochemical Society Transactions·E H KarunanayakeG Mellows

Synthesis and electron spin resonance study of spin-labelled compounds related to tumour-growth inhibitory nitroarylaziridines.

May 1, 1976·Zeitschrift Für Naturforschung. Section C: Biosciences·N J DoddP N Preston

Loss of the post-translational control of nutrient transport in vitro and in vivo virus-transformed chicken cells

Dec 1, 1976·Journal of Cellular Physiology·J F Perdue

Regulation of amino acid and glucose transport activity expressed in isolated membranes from untransformed and SV 40-transformed mouse fibroblasts

Dec 1, 1976·Journal of Cellular Physiology·J E Lever

Amino acid transport by membrane vesicles of virally transformed and nontransformed cells: effects of sodium gradient and cell density

Dec 1, 1976·Journal of Cellular Physiology·J R ParnesK J Isselbacher

Induction of neurogenic tumors by nitrosotrialkylureas in rats

Aug 8, 1975·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·W Lijinsky, H W Taylor

Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R L Margolis, L Wilson

Genetic effects of some new bifunctional and water-soluble analogs of the anti-cancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in Saccharomyces cerevisiae.

Jan 1, 1977·Mutation Research·D Siebert, G Eisenbrand

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

Jul 28, 1978·Biochemical and Biophysical Research Communications·J R Babson, D J Reed

Nitrosourea-induced DNA single-strand breaks

May 15, 1979·Biochemical Pharmacology·J W Lown, L W McLaughlin

Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents

Jan 1, 1979·Journal of Medicinal Chemistry·A M CriderJ A Clemens

Synthesis and activities of antitumor agents

Mar 1, 1979·Journal of Medicinal Chemistry·T SuamiT Hisamatsu

Synthesis and antitumor activity of water-soluble (2-chloroethyl)nitrosoureas

Mar 1, 1979·Journal of Medicinal Chemistry·T SuamiW T Bradner

The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion

Jan 1, 1979·Nucleic Acids Research·W J Bodell, M R Banerjee

Mechanism of action of the nitrosoureas -- III. Reactions of bis-chloroethyl nitrosourea and bis-fluoroethyl nitrosourea with adenosine

Apr 1, 1979·Biochemical Pharmacology·W P Tong, D B Ludlum

Reversal of the cytotoxicity of 3'-amino-3'-deoxythymidine by pyrimidine deoxyribonucleosides

Apr 1, 1979·Biochemical Pharmacology·P H FischerW H Prusoff

A structure--activity study of seven new water soluble nitrosoureas

Apr 15, 1979·Biochemical Pharmacology·J M HealP S Schein

Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5

Jun 28, 1979·Nature·R S Day, C H Ziolkowski

Carcinogenicity of chlorinated nitrosotrialkylureas in rats

Jun 8, 1979·Journal of Cancer Research and Clinical Oncology·W Lijinsky, H W Taylor

Nitrosoureidonucleosides.

Sep 1, 1979·Journal of Medicinal Chemistry·J A Montgomery, H J Thomas

Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Nature of the chemical reactions with deoxyribonucleic acid.

Jul 15, 1979·Biochemical Pharmacology·J W Lown, L W McLaughlin

Mechanism of action of the nitrosoureas: formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine.

Oct 12, 1979·Biochemical and Biophysical Research Communications·C T GombarD B Ludlum

Reactions of 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in aqueous solution.

Oct 1, 1979·Journal of Medicinal Chemistry·R J Weinkam, H S Lin

Specific protection against the cytotoxicity of a new class of nitrosoureas by pyrimidine deoxyribonucleosides.

Oct 1, 1979·Biochemical Pharmacology·P H FischerW H Prusoff

Synthesis and physico-chemical properties of 1-(2-chloroethyl)-3-(4-substituted-2,3-dioxo-1-piperazinylalkyl)-1-nitrosourea (author's transl)

Jul 1, 1979·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·T HoriI Saikawa

Structure-antitumor activity relationship of 1-(2-chloroethyl)-3-(4-substituted-2,3-dioxo-1-piperazinylalkyl)-1-nitrosourea (author's transl)

Jul 1, 1979·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·T HoriI Saikawa

Synthesis of purine nucleoside nitrosoureas and their antitumor activities

Mar 1, 1979·Chemical & Pharmaceutical Bulletin·A SatoT Hirata

Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine

Jan 1, 1978·Journal of Medicinal Chemistry·T S LinW H Prusoff

Evaluation of the role of isocyanates in the action of therapeutic nitrosoureas

May 1, 1978·Biochemical Pharmacology·J HiltonS Sargent

Mechanism of action of the nitrosoureas--II. Formation of fluoroethylguanosine from the reaction of bis-fluoroethyl nitrosourea and guanosine

Jan 1, 1978·Biochemical Pharmacology·D B Ludlum, W P Tong

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Citations

DFT investigations of phosphotriesters hydrolysis in aqueous solution: a model for DNA single strand scission induced by N-nitrosoureas.

Sep 25, 2012·Journal of Molecular Modeling·Tingting LiuRugang Zhong

Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin

Feb 28, 2004·European Journal of Medicinal Chemistry·Mekki KadriJean-Louis Montero

N-NO2 bond dissociation energies in acetonitrile: an assessment of contemporary computational methods

Jun 4, 2013·Journal of Molecular Graphics & Modelling·Xiao-Hong LiXian-Zhou Zhang

Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs

Oct 8, 1999·Pharmacology & Therapeutics·G M Dubowchik, M A Walker

Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines

Apr 2, 2003·European Journal of Medicinal Chemistry·Jean Yves WinumJean Louis Montero

Spin labeled antioxidants protect bacteria against the toxicity of alkylating antitumor drug CCNU

Aug 21, 2003·Toxicology Letters·Vesselina GadjevaAntoaneta Zheleva

Estimation of carcinogenicity using molecular fragments tree

Jul 28, 2012·Journal of Chemical Information and Modeling·Yong WangKaixian Chen

Quantitative structure-carcinogenicity relationship for detecting structural alerts in nitroso compounds: species, rat; sex, female; route of administration, gavage

Feb 26, 2008·Chemical Research in Toxicology·Aliuska Morales HelgueraMiguel Angel Cabrera Pérez

Quantitative structure-activity relationship modelling of the carcinogenic risk of nitroso compounds using regression analysis and the TOPS-MODE approach

Jun 15, 2010·SAR and QSAR in Environmental Research·A M HelgueraR D Combes

N -ethyl- N -nitrosourea induces retinal photoreceptor damage in adult rats.

Apr 7, 2012·Journal of Toxicologic Pathology·Katsuhiko YoshizawaAiro Tsubura

Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40

Mar 5, 2011·Biochemical Pharmacology·Anna TrzeciakiewiczFrançoise Degoul

An accurate nonlinear QSAR model for the antitumor activities of chloroethylnitrosoureas using neural networks

Mar 1, 2011·Journal of Molecular Graphics & Modelling·Yu QinRugang Zhong

Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds

May 5, 2007·Toxicology and Applied Pharmacology·Aliuska Morales HelgueraMiguel Angel Cabrera Pérez

Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry

Jun 24, 2011·Rapid Communications in Mass Spectrometry : RCM·Baoqing BaiRugang Zhong

Solvent effects of N-nitroso, N-(2-chloroethyl), N',N'-dibenzylsulfamid and its copper(II) and cobalt(II) complexes: fluorescence studies

Jan 10, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Nadjia BensouilahMohamed Abdaoui

Quantification of DNA interstrand crosslinks induced by ACNU in NIH/3T3 and L1210 cells using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry

Feb 6, 2014·Rapid Communications in Mass Spectrometry : RCM·Lili LiRugang Zhong

Spectrofluorimetric determination of the antineoplastic agent lomustine based on the sensitizing effect of β-cyclodextrin

Oct 30, 2015·Luminescence : the Journal of Biological and Chemical Luminescence·Hassina FisliMohamed Abdaoui

Epidermal growth factor receptor inhibitors: a patent review (2010 - present)

Jan 7, 2014·Expert Opinion on Therapeutic Patents·Si-Ning Li, Huan-Qiu Li

Antitumor sulfonylhydrazines: design, structure-activity relationships, resistance mechanisms, and strategies for improving therapeutic utility

Jan 23, 2015·Journal of Medicinal Chemistry·Krishnamurthy ShyamAlan C Sartorelli

From old alkylating agents to new minor groove binders

Aug 27, 2013·Critical Reviews in Oncology/hematology·Stéphane PuyoPhilippe Pourquier

Protective effect of spin-labeled 1-ethyl-1-nitrosourea against oxidative stress in liver induced by antitumor drugs and radiation

Nov 1, 2013·BioMed Research International·V GadjevaM Vasileva

Nitric oxide and free stable nitroxyl radicals in the mechanism of biological action of the spin-labeled compounds

Aug 23, 2001·Medical Hypotheses·Z D RaikovA T Atanasov

Biological evaluation of new potential anticancer agent for tumour imaging and radiotherapy by two methods: (99m)Tc-radiolabelling and EPR spectroscopy

May 29, 2015·Biotechnology, Biotechnological Equipment·Yanka KaramalakovaAnil Mishra

Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry

Mar 24, 2015·PloS One·Lili LiRugang Zhong

Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry

Jun 11, 2014·Chemical Research in Toxicology·Guohui SunRugang Zhong

The first O-NO bond energy scale in solution: heterolytic and homolytic cleavage enthalpies of O-nitrosyl carboxylate compounds

May 18, 2000·Organic Letters·M XianJ P Cheng

Man-made cytotoxic steroids: exemplary agents for cancer therapy

May 30, 2014·Chemical Reviews·Ranju Bansal, Pratap Chandra Acharya

Nitrosation of amides involves a pseudopericyclic 1,3-sigmatropic rearrangement

Feb 28, 2004·Organic Letters·David M Birney

Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea

Apr 19, 2011·Toxicologic Pathology·Katsuhiko YoshizawaAiro Tsubura

Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety

Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingzi LiuBin He

Theoretical study of some nitrososulfamide compounds with antitumor activity.

Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khatmi DjameleddineMadi Fatiha

Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide

Nov 18, 2005·Bioorganic & Medicinal Chemistry Letters·Achour SeridiJean-Louis Montero

Improving the accuracy of Density Functional Theory (DFT) calculation for homolysis bond dissociation energies of Y-NO bond: generalized regression neural network based on grey relational analysis and principal component analysis.

Jul 7, 2011·International Journal of Molecular Sciences·Hong Zhi LiZhong Min Su

A promising tool to achieve chemical accuracy for density functional theory calculations on Y-NO homolysis bond dissociation energies.

Sep 4, 2012·International Journal of Molecular Sciences·Hong Zhi LiZhong Min Su

Study on the decomposition of 2-chloroethylnitro- sosulfamides (CENS) in serum using HPLC on-line solid phase extraction

Aug 25, 2006·Archiv der Pharmazie·Achour SeridiJean-Louis Montero

Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride

Aug 5, 2010·Organic & Biomolecular Chemistry·Sonja StankovićNorbert De Kimpe

Cytotoxicity of lysomustine and its isomers, and their potential use for selection of cells

Apr 14, 2012·Bioorganicheskaia khimiia·F N RozovV P Krasnov

Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression

Sep 13, 2003·The Journal of Pharmacology and Experimental Therapeutics·Isabelle PassagneLaurence Vian

Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells.

Dec 7, 2007·Journal of Neuro-oncology·Zakia ShinwariAbdelilah Aboussekhra

URD12: A urea derivative with marked antitumor activities.

Jun 29, 2012·Oncology Letters·Ai-Yun WangQing-Cai Jiao

Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation

Dec 19, 2019·International Journal of Molecular Sciences·Weinan XiaoRugang Zhong

In Silico Prediction of O⁶-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods

Nov 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guohui SunYongzhen Peng

Susceptibility to N-methyl-N-nitrosourea-induced retinal degeneration in different rat strains

Mar 19, 2016·Journal of Toxicologic Pathology·Yuko EmotoAiro Tsubura

Alkylating agents

Oct 25, 2011·Bulletin du cancer·Philippe Pourquier

Cell Models for Birth Defects Caused by Chloroethylnitrosourea-induced DNA Lesions

Aug 18, 2020·The Journal of Craniofacial Surgery·Jiankun CaoShuyan Qie

The relationship between solvatochromic properties and in silico ADME parameters of new chloroethylnitrosourea derivatives with potential anticancer activity and their β-Cyclodextrin complexes.

Feb 22, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hassina FisliMohamed Abdaoui

Cell Models for Birth Defects Caused by Chloroethyl Nitrosourea-Induced DNA Lesions.

Mar 12, 2021·The Journal of Craniofacial Surgery·Jiankun CaoShuyan Qie

3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells

Apr 25, 2020·Biochemical Pharmacology·Xiaodong SunYongzhen Peng

Establishment of heterolytic and homolytic Y-NO2 bond dissociation energy scales of nitro-containing compounds in acetonitrile: chemical origin of NO2 release and capture

Mar 1, 2008·The Journal of Organic Chemistry·Xin LiJin-Pei Cheng

Unusual deoxygenation and reactivity studies related to O6-(benzotriazol-1-yl)inosine derivatives

Jan 22, 2008·The Journal of Organic Chemistry·Suyeal Bae, Mahesh K Lakshman

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