A critical appraisal of the use of recombinant factor VIIa in acquired bleeding conditions

British Journal of Haematology
Sajjan Mittal, Henry G Watson

Abstract

Recombinant activated factor VII (rVIIa) was initially used for the treatment of inhibitors in patients with haemophilia. However, its localised mode of action at sites of damage to the vessel combined with dramatic clinical observations in exsanguinating patients have resulted in huge interest in its use as a global haemostatic agent. Although it appears safe, with no obvious excess of thrombotic events, its use in assorted acquired bleeding disorders, especially those associated with the development of complex coagulopathies, such as in the post-trauma state, has proved to be less dramatic than hoped.

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Citations

Aug 30, 2008·British Journal of Haematology·Drew ProvanRoberto Stasi
Nov 28, 2006·International Journal of Obstetric Anesthesia·D Karalapillai, P Popham
Jun 6, 2014·Psychological Reports·Fa-Chung Chiu, Priscilla L P Tu
May 17, 2008·The American Surgeon·John D HortonMichel Wagner

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