PMID: 1197395Jul 1, 1975Paper

A critical evaluation of body weight loss following lateral hypothalamic lesions

Physiology & Behavior
L E HarrellS Balagura

Abstract

The possibility that factors in addition to motivational or psychomotor deficits contribute to body weight losses following lateral hypothalamic (LH) lesions was assessed in 2 experiments. Rats with LH lesions failed to gain weight when compared to sham-operated controls, when equal quantities of nutrients were given by intragastric feeding. They also lost weight more rapidly than controls under total starvation conditions regardless of whether food was present or absent in the G1 tract prior to surgery. These results could not be explained on the basis of differences in urine or fecal output or activity levels. An increase in core temperature was found in LH lesioned rats immediately following surgery and throughout the experimental period. These results suggest that lateral hypothalamic lesions induce a metabolic impairment.

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Citations

Sep 1, 1986·Metabolism: Clinical and Experimental·L N KaufmanR E Keesey
Sep 1, 1978·Physiology & Behavior·T SchallertJ J Braun
Feb 1, 1984·Physiology & Behavior·R E KeeseyL N Kaufman
Jan 1, 1986·Physiology & Behavior·R Refinetti, H J Carlisle
Nov 1, 1990·Pharmacology, Biochemistry, and Behavior·L L BernardisA Awad
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Jan 1, 1979·Psychoneuroendocrinology·J PankseppJ Rossi
Sep 1, 1983·The Journal of Clinical Investigation·T YoshidaG A Bray
Dec 24, 2013·Journal of Neurosurgery·Asem Salma, Faisal Al-Otaibi
Jul 28, 2004·Brain Research Bulletin·Vinuta Rau, Carlos V Grijalva
Aug 2, 2018·Neurosurgical Focus·Alexander C WhitingDonald M Whiting
Apr 4, 2020·Obesity·Lee M Kaplan, Anthony G Comuzzie
Apr 1, 1982·The American Journal of Physiology·S W Corbett, R E Keesey
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Sep 29, 2021·Stereotactic and Functional Neurosurgery·William Omar Contreras LópezSantiago Crispín

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