Jun 11, 1976

A critical evaluation of the relationship between the presynaptic network, synaptic vesicles and dense projections in central synapses

Cell and Tissue Research
D G JonesM M Dittmer


Synapses of the oculomotor nucleus of Echidna have been examined ultrastructurally with the aim of integrating data obtained from osmicated and nonosmicated PTA stained material. Particular emphasis has been laid on the relationship between the synaptic vesicles of the osmicated material and the presynaptic network and vesicular grid of the PTA material. This relationship has been explored qualitatively by examining osmicated material of varying qualities of fixation. Such material contains dense projections in addition to synaptic vesicles, and various vesicular network appearances. A variety of measurement techniques have shown that the PTA network is characterised by reticular strands, spaces, and regular hexagonal units smaller than vesicles, these observations prompting the formulation of a "vesicle-network coincidence" model of the presynaptic terminal. This model has been tested by tracing the profiles of vesicles within the PTA network and comparing their size and shape frequency distributions with those of osmicated synaptic vesicles. The distributions have been found to be essentially similar, suggesting that vesicles can be located within the network, and that the hexagonal network units are formed only in the presen...Continue Reading

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Mentioned in this Paper

Presynaptic Terminals
Projections and Predictions
Spiny Anteater
Synaptic Vesicles
Sample Fixation
Staining and Labeling
Phosphotungstic Acid

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