A critical Examination of the Phenomenon of Bonding Area - Bonding Strength Interplay in Powder Tableting

Pharmaceutical Research
Frederick Osei-YeboahChangquan Calvin Sun

Abstract

Although the bonding area (BA) and bonding strength (BS) interplay is used to explain complex tableting behaviors, it has never been experimentally proven. The purpose of this study is to unambiguously establish the distinct contributions of each by decoupling the contributions from BA and BS. To modulate BA, a Soluplus® powder was compressed into tablets at different temperatures and then broken following equilibration at 25°C. To modulate BS, tablets were equilibrated at different temperatures. To simultaneously modulate BA and BS, both powder compression and tablet breaking test were carried out at different temperatures. Lower tablet tensile strength is observed when the powder is compressed at a lower temperature but broken at 25°C. This is consistent with the increased resistance to polymer deformation at lower temperatures. When equilibrated at different temperatures, the tensile strength of tablets prepared under identical conditions increases with decreasing storage temperature, indicating that BS is higher at a lower temperature. When powder compression and tablet breaking are carried out at the same temperature, the profile with a maximum tensile strength at 4°C is observed due to the BA-BS interplay. By systematical...Continue Reading

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Citations

Apr 12, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Changquan Calvin Sun, Peter Kleinebudde
May 1, 2016·International Journal of Pharmaceutics·Sarsvat Patel, Changquan Calvin Sun
Sep 22, 2016·Journal of Pharmaceutical Sciences·Shubhajit PaulChangquan Calvin Sun
Oct 23, 2016·Journal of Pharmaceutical Sciences·Sarsvat PatelChangquan Calvin Sun
Apr 27, 2017·Molecular Pharmaceutics·Shao-Yu Chang, Changquan Calvin Sun
May 10, 2017·Journal of Pharmaceutical Sciences·Shubhajit PaulChangquan Calvin Sun
Oct 3, 2018·Chemistry : a European Journal·Sunil SeethaLekshmiSunil Varughese
Oct 30, 2019·Pharmaceutical Research·Alexander KaliesClaudia S Leopold
Jan 25, 2021·International Journal of Pharmaceutics·Oisín N KavanaghChangquan Calvin Sun
Sep 11, 2020·Journal of Pharmaceutical Sciences·Shubhajit PaulChangquan Calvin Sun
Dec 25, 2019·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Shao-Yu Chang, Changquan Calvin Sun
Jun 25, 2019·Journal of Pharmaceutical Sciences·Rahul Roopwani, Ira S Buckner
Mar 6, 2019·Molecular Pharmaceutics·Chenguang Wang, Changquan Calvin Sun
Feb 15, 2020·Molecular Pharmaceutics·Shubhajit PaulChangquan Calvin Sun
Oct 4, 2020·International Journal of Pharmaceutics·Jiangnan DunChangquan Calvin Sun

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