A critical maturational period of reduced brain vulnerability to developmental injury. I. Behavioral studies in cats

Brain Research. Developmental Brain Research
J R VillablancaD A Hovda

Abstract

Groups of cats with resection of the neocortex of the left cerebral hemisphere at postnatal (P) ages (in days) 5-15 (P10), 30 (P30), 60 (P60), 90 (P90), 120 (P120), and in adulthood, were compared using a comprehensive battery of 16 neurobehavioral tests administered when they were at least 6 months post-lesion. For all behaviors, except 3 (including the paw contact placing reaction which never recovered), the performance was significantly better for the cats lesioned between P10 and P30 compared to cats lesioned at older ages. For 10 of the behaviors, the transition from age-at-lesion P30 to P60 was rather abrupt and characterized by a significant increment in impairments. However, cats with the resection at ages P90 and P120 still showed some behavioral advantage over the adult-lesioned animals. Overall, for most of the behaviors tested, there was a significant linear trend for an increase in the magnitude of impairments across the entire age-at-lesion range. We previously reported that cats with a unilateral frontal cortical lesion sustained during the late fetal life showed substantial behavioral impairments, while animals with a similar resection sustained early postnatally exhibited minimal abnormalities. These findings, ...Continue Reading

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Citations

Sep 24, 1999·Journal of Neuroscience Research·J C McEachern, C A Shaw
Aug 1, 2000·Brain Research. Developmental Brain Research·J R VillablancaH A Crutcher
Aug 1, 2000·Brain Research. Developmental Brain Research·J R VillablancaK Tavabi
Nov 24, 2001·Brain Research. Developmental Brain Research·T D Schmanke, J R Villablanca
Feb 12, 2000·Neuroscience·J R Villablanca, D A Hovda
Apr 5, 2003·Journal of Neurotrauma·Mayumi L Prins, David A Hovda
Jul 26, 2011·Brain : a Journal of Neurology·Vicki AndersonAmanda Wood
Sep 22, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Sunita BavaDoris A Trauner
Sep 1, 2006·Developmental Neuroscience·Patrick M Kochanek
Aug 2, 2011·Behavioural Brain Research·Farshad Nemati, Bryan Kolb
Jan 2, 2007·Brain Research·J Wesley Burgess, Jaime R Villablanca
Jan 10, 2002·Brain and Language·S CurtissG W Mathern
Feb 25, 2018·Neurocritical Care·Ajit SarnaikUNKNOWN Investigators of the ADAPT Trial
Jun 18, 2020·Applied Neuropsychology. Adult·Thomas G BurnsAndrew Reisner

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