A critical period for reduced brain vulnerability to developmental injury. II. Volumetric study of the neocortex and thalamus in cats

Brain Research. Developmental Brain Research
T D SchmankeH M Patel

Abstract

Groups of young adult cats with a left hemineodecortication at postnatal (P) ages (in days) 5-15 (P10), 30 (P30) 60 (P60), 90 (P90), 120 (P120) and in adulthood, were used to measure the volume of the thalamus, bilaterally, and of the remaining neocortex (right hemisphere). The same subjects were employed for the behavioral studies reported in the preceding paper. There was a bilateral, age-dependent, thalamic volume decrease. Ipsilateral to the resection, the thalamic shrinkage was the largest for the adult-lesioned cats (by 56.7%) and it was the smallest for the P30 group (43.4%), with a tendency towards a greater atrophy as the age at lesion increased. A similar pattern of atrophy was seen for the contralateral thalamus but the volume reduction was much less pronounced such that it was significant only for the four older age-at-lesion groups (ranging from 18.2% to 11.2% for the P120 and P90 groups respectively). Once again, the shrinkage was the smallest for the P30 group (5.3%). The remaining neocortex also shrunk in these animals, but the volume decrease was significant only for the adult-lesioned (17.8%) and the P120 group (15.4%), while the P30 group had practically no shrinkage (2.4%). The frontal cortex had no atrophy ...Continue Reading

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Citations

Aug 1, 2000·Brain Research. Developmental Brain Research·J R VillablancaH A Crutcher
Aug 1, 2000·Brain Research. Developmental Brain Research·J R VillablancaK Tavabi
Nov 24, 2001·Brain Research. Developmental Brain Research·T D Schmanke, J R Villablanca
Jun 13, 1998·Brain Research. Developmental Brain Research·J R VillablancaD A Hovda
Feb 12, 2000·Neuroscience·J R Villablanca, D A Hovda
Apr 5, 2003·Journal of Neurotrauma·Mayumi L Prins, David A Hovda
Sep 22, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Sunita BavaDoris A Trauner
Jan 2, 2007·Brain Research·J Wesley Burgess, Jaime R Villablanca
Mar 14, 2002·Developmental Psychobiology·Pamela Moses, Joan Stiles

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