A critical period of transcription required for differentiation of the action potential of spinal neurons.

Neuron
A B Ribera, N C Spitzer

Abstract

The early development of excitability of amphibian spinal neurons is characterized by a change from a long Ca2(+)-dependent action potential to a brief Na(+)-dependent impulse. The delayed rectifier K+ current plays a major role in this cell autonomous differentiation. Here we show that the maturation of the delayed rectifier current, and hence the action potential, involves a critical period of mRNA synthesis. It is blocked by inhibition of transcription during an early period of development in culture and fails to develop following removal of the inhibitor and resumption of RNA synthesis. However, the development of an inactivating K+ A-current recovers in these neurons, indicating that some programs of neuronal development are affected during this critical period, while others are spared.

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Citations

Jul 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N R CashmanJ P Antel
Mar 1, 1991·Developmental Biology·A B Ribera, N C Spitzer
Apr 1, 1994·Brain Research. Molecular Brain Research·T SkutellaG F Jirikowski
Jul 22, 1999·Annals of the New York Academy of Sciences·A B Ribera
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ricardo H Pineda, Angeles B Ribera
Apr 23, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qian XiaoNicholas C Spitzer
Nov 1, 1993·The Journal of Comparative Neurology·N C SpitzerJ Holliday
Jun 18, 2002·The Journal of Physiology·Meredith A LazaroffAngeles B Ribera
Aug 6, 2008·The Journal of Comparative Neurology·Nicole G GravagnaAngeles B Ribera
Aug 13, 2004·Journal of Neurophysiology·Judith T BlaineAngeles B Ribera
Jan 28, 2005·Journal of Neurophysiology·Ricardo H PinedaAngeles B Ribera
Jul 18, 2003·Journal of Neurophysiology·Manuel KukuljanAngeles B Ribera
Apr 1, 2021·Cold Spring Harbor Protocols·Ben G Szaro
Jul 3, 2013·Cold Spring Harbor Protocols·Nicholas C SpitzerCory M Root

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