A critical question for NEC researchers: Can we create a consensus definition of NEC that facilitates research progress?

Seminars in Perinatology
Phillip V GordonRobert D Christensen

Abstract

In the last decades the reported incidence of preterm necrotizing enterocolitis (NEC) has been declining in large part due to implementing comprehensive NEC prevention initiatives, including breast milk feeding, standardized feeding protocols, transfusion guidelines, and antibiotic stewardship and improving the rigor with which non-NEC cases are excluded from NEC data. However, after more than 60 years of NEC research in animal models, the promise of a "magic bullet" to prevent NEC has yet to materialize. There are also serious issues involving clinical NEC research. There is a lack of a common, comprehensive definition of NEC. National datasets have their own unique definition and staging definitions. Even within academia, randomized trials and single center studies have widely disparate definitions. This makes NEC metadata of very limited value. The world of neonatology needs a comprehensive, universal, consensus definition of NEC. It also needs a de-identified, international data warehouse.

References

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Citations

Dec 18, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anne E van HeesewijkSara B DeMauro
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Dec 29, 2020·Frontiers in Pediatrics·Eduardo Villamor-MartinezEduardo Villamor
Feb 17, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Darius JavidiNaveed Hussain
Dec 26, 2017·Seminars in Pediatric Surgery·Matthew W RallsMisty Good
May 26, 2021·Clinics in Perinatology·Jennifer DuchonPatricia W Denning
Jul 15, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Janet Berrington, Nicholas D Embleton
May 8, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Rachael E Andrews, Kristi L Coe

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