A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and chronic traumatic encephalopathy.

European Journal of Nuclear Medicine and Molecular Imaging
Cyrus AyubchaAbass Alavi

Abstract

Positron emission tomography (PET) has been widely utilized in the study of traumatic brain injury (TBI) for decades. While most applications of PET have attempted to assess neuronal function after TBI, more recently, novel radiotracers have sought to image biomarkers in the context of TBI and chronic traumatic encephalopathy (CTE). This review will begin with an overview of TBI and CTE along with the acute and chronic pathophysiological consequences of TBI. Next, glycolysis, beta-amyloid, and tau protein radiotracers will be critically assessed in light of the most recent imaging studies available. Based on the scientific relevance of such radiotracers to the molecular processes of TBI and CTE along with the broader evidence of radiotracer specificity and selectivity, this review will weigh the strengths and weaknesses of each radiotracer. Nonetheless, the evidence indicates that PET will continue to be a powerful modality in the diagnosis of TBI-related conditions.

References

Apr 1, 1994·Journal of Neurotrauma·C W ChristmanJ T Povlishock
Mar 1, 1995·Developmental Medicine and Child Neurology·G WorleyW J Oakes
Sep 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·J E AhlskogE Kokmen
Oct 1, 1995·Brain Pathology·D I GrahamT A Gennarelli
Nov 25, 2000·Nuclear Medicine and Biology·S C Huang
Nov 13, 2001·Journal of Neurosurgery·H L LaurerT K McIntosh
Jan 15, 2002·DNA and Cell Biology·J F LoringR Somogyi
Feb 13, 2002·Seminars in Nuclear Medicine·Abass Alavi, Martin Reivich
May 7, 2002·Journal of Neurotrauma·S Michelle DeFordRobert J Hamm
Nov 8, 2002·Archives of Physical Medicine and Rehabilitation·Eric M UmileRosette C Plotkin
Mar 6, 2004·Journal of Neurotrauma·Hsiao-Ming WuMarvin Bergsneider
Jun 15, 2004·Medical Hypotheses·Russell H Swerdlow, Shaharyar M Khan
Jul 28, 2004·International Review of Psychiatry·Laurie M Ryan, Deborah L Warden
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roger S ArmenValerie Daggett
Nov 13, 2004·Journal of Cell Science·Gail V W Johnson, William H Stoothoff
Jan 10, 2006·Annals of the New York Academy of Sciences·S M McCannV Rettori
May 24, 2006·Annals of Neurology·Samuel M GoldmanJ William Langston
Sep 20, 2006·The Journal of Head Trauma Rehabilitation·Jean A LangloisMarlena M Wald
Aug 19, 2007·Brain : a Journal of Neurology·A LockhartT G Beach
Feb 20, 2009·Journal of Neurochemistry·Paul W ThompsonAndrew Lockhart
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jenna M Ziebell, Maria Cristina Morganti-Kossmann
Jun 22, 2010·The Tohoku Journal of Experimental Medicine·Yuko NakajimaTakashi Tsubokawa
Jul 1, 2010·Alzheimer's Research & Therapy·Brandon E GavettAnn C McKee
Aug 4, 2010·Current Alzheimer Research·K IqbalI Grundke-Iqbal
Aug 19, 2010·Nuclear Medicine Communications·Frank Anthony ProvenzanoMasanori Ichise
Nov 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ying R LiuViviane Bouilleret
Nov 16, 2010·Clinics in Sports Medicine·David F Meaney, Douglas H Smith

❮ Previous
Next ❯

Citations

Apr 3, 2021·Frontiers in Neuroscience·Suna HuangYujie Chen
May 15, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Grant RigneyAbass Alavi
May 24, 2021·Acta Neuropathologica Communications·Breton M Asken, Gil D Rabinovici
Jul 27, 2021·Pediatric Neurology·Stephen AshwalChristopher G Wilson
Oct 26, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M L Chukhlovina, A A Chukhlovin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.