A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing.

Analytical and Bioanalytical Chemistry
Laura RolingerJürgen Hubbuch

Abstract

As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and address the recent innovations and applications of spectroscopic methods as PAT tools in the downstream processing of biologics. As data analysis strategies are a crucial part of PAT, the review discusses frequently used data analysis techniques and addresses data fusion methodologies as the combination of several sensors is moving forward in the field. The last chapter will give an outlook on the application of spectroscopic methods in combination with chemometrics and model predictive control (MPC) for downstream processes. Graphical abstract.

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Citations

Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel Cozzolino
Sep 19, 2020·Biotechnology and Bioengineering·Dhanuka P WasalathanthriZheng Jian Li
Jan 15, 2021·Nanomaterials·Hartmut HillmerThomas Kusserow
Apr 26, 2021·Biotechnology Advances·Jorge JoãoAna M Azevedo
May 12, 2021·Biotechnology Advances·Ipek SüntarSolomon Habtemariam

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Methods Mentioned

BETA
deamidation
Fluorescence
fluorescence spectroscopy
protein
light scattering
infrared spectroscopy
static light scattering
PCA
optical spectroscopy

Software Mentioned

Raman
MIR
PAT
ALS

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