A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain

Neuroscience
S T Meller, G F Gebhart

Abstract

There is considerable evidence that on the anterior surface of the heart (which is usually supplied by the left anterior descending and the proximal part of the left circumflex coronary arteries), sympathetic efferent reflexes characterized by tachycardia and/or hypertension predominate following experimental or pathological perturbations. These cardiovascular reflexes are accompanied by an increase in presumed nociceptive afferent traffic and, in pathological condition, by pain. In these experiments, there is generally no effect of vagotomy on afferent nerve traffic, and lower cervical and upper thoracic sympathectomies help provide relief from angina. On the other hand, experimental or pathological perturbations involving the inferior-posterior surface of the heart (supplied by the right and distal parts of the left circumflex coronary arteries), are characterized by vagal efferent reflexes, resulting in bradycardia and/or hypotension. These reflexes are accompanied by an increase in vagal afferent nerve traffic and, in pathological conditions, by pain. In these experiments, vagotomy generally abolishes such cardiovascular reflexes, and lower cervical and upper thoracic sympathectomies are not effective in the relief from ang...Continue Reading

References

Sep 1, 1977·Clinical and Experimental Pharmacology & Physiology·J Staszewska-Barczak, G J Dusting
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J A EstrinI J Fox
Oct 22, 1979·The American Journal of Cardiology·T N JamesF Urthaler
Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T H HintzeG Kaley
May 1, 1977·Physiology & Behavior·D S Bachman, H M Katz
Jul 1, 1979·British Heart Journal·F Perez-GomezA Garcia Aguado
Nov 25, 1977·Pflügers Archiv : European journal of physiology·K NishiF Takenaka
Feb 1, 1978·The Annals of Thoracic Surgery·S J Dos
Jun 15, 1978·European Journal of Pharmacology·F Riccioppo Neto
Sep 1, 1977·British Heart Journal·F Perez-Gomez, A Garcia-Aguado
Jul 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·F LembeckH Juan
Mar 1, 1975·Microvascular Research·M K WhiteD Shepro
Jan 1, 1975·Circulation Research·A J BlockJ R Vane
May 1, 1986·Journal of Cardiovascular Pharmacology·R Verheggen, K Schrör
Feb 14, 1989·European Journal of Pharmacology·H E ConnorP P Humphrey
Nov 1, 1989·Anesthesia and Analgesia·T N James
Jan 1, 1989·The Japanese Journal of Physiology·P PalB Koley
Apr 1, 1989·Journal of the Autonomic Nervous System·D A Hopkins, J A Armour
Oct 13, 1987·Brain Research·Y O TaiwoJ D Levine
Jun 1, 1987·Journal of the American College of Cardiology·S C WebbP A Poole-Wilson
Feb 1, 1986·Clinical Physiology·B B Fredholm, A Sollevi
Jul 26, 1986·British Medical Journal·C SylvénR Brandt
Sep 6, 1986·British Medical Journal·V K PuriK P Bhargava
Oct 18, 1986·British Medical Journal·C SylvénB Jonzon
Nov 1, 1988·Hypertension·S GhioneE Panattoni
Jan 1, 1988·Cardiology·G FerroM Chiariello
Mar 1, 1987·Progress in Cardiovascular Diseases·R A Olsson, R Bünger

❮ Previous
Next ❯

Citations

Jun 18, 1999·Herz·A WilkeB Maisch
Mar 4, 2008·Journal of Physiology and Biochemistry·C P ZhangF Wan
Feb 19, 2013·Pflügers Archiv : European journal of physiology·Tomohiro NumataYasuo Mori
Jan 1, 1993·Agents and Actions. Supplements·K M HargreavesJ Q Swift
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven FalowskiAshwini Sharan
Aug 12, 1999·European Journal of Pharmacology·D A Kharkevich, V V Churukanov
Jul 16, 1994·Lancet·S D RosenP G Camici
Feb 22, 2001·International Journal of Cardiology·V CulićD Eterović
May 30, 2002·Progress in Neurobiology·Mark J Millan
Feb 13, 1999·Progress in Neurobiology·M J Millan
Mar 26, 1999·Journal of the American College of Cardiology·H E BøtkerF Andreasen
Mar 27, 2003·Bioorganic & Medicinal Chemistry Letters·Mark A YoungmanMichele C Jetter
Mar 29, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C Leopold, R Schandry
Jan 5, 2002·Autonomic Neuroscience : Basic & Clinical·C J JouR D Foreman
Oct 12, 2000·Acta Anaesthesiologica Scandinavica·H T Sommerschild, K A Kirkebøen
Aug 10, 2000·British Journal of Clinical Pharmacology·R J EdwardsM S Marber
Sep 6, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M GschossmannH E Raybould
Nov 28, 2002·Headache·Giuseppe FamularoPaolo Tarroni
Dec 25, 2008·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Uri SendovskiMoshe George Rothmann
Mar 11, 2004·Cephalalgia : an International Journal of Headache·P Sathirapanya
May 29, 2008·Cephalalgia : an International Journal of Headache·J-H Wei, H-F Wang
Apr 1, 1999·Annual Review of Physiology·R D Foreman
Feb 18, 2011·American Journal of Physiology. Cell Physiology·Bai-Yan LiJohn H Schild
Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Liang-Wu Fu, John C Longhurst
Jun 17, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heidi L LujanStephen E Dicarlo
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Xiaohui DingCarole A Williams
Mar 14, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·David D Gutterman
Jul 25, 2012·Surgical Neurology International·Scott E Krahl
Oct 21, 2000·Lancet·G A LanzaA Maseri
Oct 12, 2010·Future Cardiology·Rui Andre Providencia
Apr 27, 1996·Lancet·D M YellonM S Marber
Jun 7, 2014·Der Schmerz·W Jänig
Oct 16, 2014·American Journal of Respiratory and Critical Care Medicine·Sarah A ImmanuelMathias Baumert
Aug 30, 2011·Nature Chemical Biology·Nobuaki TakahashiYasuo Mori
Jul 10, 2014·PloS One·Luciana Mesquita PassamaniJulian Francis Richmond Paton
Sep 10, 2003·American Journal of Physical Medicine & Rehabilitation·Jason S LipetzJeff Silber
Mar 21, 2012·The Canadian Journal of Cardiology·Stuart D Rosen

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