A Critical Review of the Properties of Fusidic Acid and Analytical Methods for Its Determination

Critical Reviews in Analytical Chemistry
Mariane Machado Curbete, Hérida Regina Nunes Salgado

Abstract

Fusidic acid, an antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids, but has no corticosteroid effects. It is indicated for the treatment of infections caused by methicillin-resistant Staphylococcus aureus strains. The aim of this study was to search for the properties of fusidic acid published so far in the literature, as well as the methods developed for its determination in biological samples and pharmaceutical formulations. From the findings, we can conclude that fusidic acid has been used for decades and is indicated for the treatment of serious infections caused by Gram-positive microorganisms to this day. Furthermore, it is a hypoallergenic agent, has low toxicity, shows low resistance, and has no cross-resistance with other clinically used antibiotics. The analytical method of high-performance liquid chromatography has been widely used for determining fusidic acid, since it can reduce the cost and time of analysis, making it more viable for routine quality control in the pharmaceutical industry.

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Citations

Jan 13, 2017·Critical Reviews in Analytical Chemistry·Guilherme Felipe Dos Santos FernandesJean Leandro Dos Santos
Dec 7, 2018·Critical Reviews in Analytical Chemistry·Karen de Souza RuganiHérida Regina Nunes Salgado
May 31, 2018·Critical Reviews in Analytical Chemistry·Mariana Nunes de MenezesHérida Regina Nunes Salgado
Apr 25, 2019·Critical Reviews in Analytical Chemistry·Guilherme Felipe Dos Santos FernandesJean Leandro Dos Santos
Jul 27, 2018·Current Drug Targets·Izabella Mogilnicka, Marcin Ufnal
Apr 24, 2020·Mediators of Inflammation·Voon Kin ChinMaha Abdullah
Dec 22, 2020·Frontiers in Bioengineering and Biotechnology·Viktor V RevinNikolay A Pestov
May 3, 2021·Antimicrobial Resistance and Infection Control·Bahareh HajikhaniMasoud Dadashi
Mar 23, 2019·Microbiology Spectrum·Martin VestergaardHanne Ingmer

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Methods Mentioned

BETA
GTPase
atomic absorption spectrometry
differential
X-ray

Software Mentioned

SciFinder

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