PMID: 6989508May 1, 1980Paper

A critical review of the use of vincristine (VCR) as a tumour cell synchronizing agent in cancer therapy

Cell and Tissue Kinetics
R S Camplejohn

Abstract

Vincristine (VCR) has been used clinically in so-called 'tumour cell synchronization therapy schedules'. These schedules are based on the assumption that cells, arrested in metaphase by low doses of VCR, subsequently re-enter the proliferative cycle synchronously. However, the evidence that tumour cell synchrony can be achieved under clinical conditions or that 'cell synchronization therapy schedules' yield a better therapeutic response than other efficient combination schemes, is scanty. Further, even in experimental systems, the efficacy of VCR as a cell synchronizing agent is disputed. Indeed, in some systems, cells arrested in metaphase by low doses of VCR, do not re-enter a normal proliferative cycle at all following arrest. In addition, the complex nature of the VCR-tumour interaction and the heterogeneous nature of the tumour cell populations against which it is used augurs badly for the successful application of cell synchronization therapy schedules.

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Citations

Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·B SchultzeW Maurer
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May 1, 1985·Cell and Tissue Kinetics·C J PritchettR G Wilson
Apr 24, 2019·International Journal of Molecular Sciences·Marta Ewelina WawroJolanta Niewiarowska

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