PMID: 11925037Apr 2, 2002Paper

A critical role for ethylene in hydrogen peroxide release during programmed cell death in tomato suspension cells

Planta
JongAnkeJ deErnst J Woltering

Abstract

Camptothecin, a topo isomerase-I inhibitor used in cancer therapy, induces apoptosis in animal cells. In tomato (Lycopersicon esculentum Mill.) suspension cells, camptothecin induces cell death that is accompanied by the characteristic nuclear morphological changes such as chromatin condensation and nuclear and DNA fragmentation that are commonly associated with apoptosis in animal systems. These effects of camptothecin can effectively be blocked by inhibitors of animal caspases, indicating that, in tomato suspension cells, camptothecin induces a form of programmed cell death (PCD) with similarities to animal apoptosis (A.J. De Jong et al. (2000) Planta 211:656-662). Camptothecin induced cell death was employed to study processes involved in plant PCD. Camptothecin induced a transient increase in H2O2 production starting within 2 h of application. Both camptothecin-induced cell death and the release of H2O2 were effectively blocked by application of the calcium-channel blocker lanthanum chloride, the caspase-specific inhibitor Z-Asp-CH2-DCB, or the NADPH oxidase inhibitor diphenyl iodonium, indicating that camptothecin exerts its effect on cell death through a calcium- and caspase-dependent stimulation of NADPH oxidase activity...Continue Reading

Citations

Jan 1, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Frank A Hoeberichts, Ernst J Woltering
Jun 30, 2005·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhi-Qiang GeYing-Jin Yuan
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Mar 8, 2005·Trends in Plant Science·Wouter G van Doorn, Ernst J Woltering
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Feb 20, 2014·Physiologia Plantarum·Rahat NazarNafees A Khan
Nov 3, 2006·Plant Physiology and Biochemistry : PPB·E T YakimovaE J Woltering

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