A critical role for the parabrachial nucleus in generating central nervous system responses elicited by a systemic immune challenge

Journal of Neuroimmunology
K M BullerT A Day

Abstract

Using Fos immunolabelling as a marker of neuronal activation, we investigated the role of the parabrachial nucleus in generating central neuronal responses to the systemic administration of the proinflammatory cytokine interleukin-1beta (1 microg/kg, i.a.). Relative to intact animals, parabrachial nucleus lesions significantly reduced the number of Fos-positive cells observed in the central amygdala (CeA), the bed nucleus of the stria terminalis (BNST), and the ventrolateral medulla (VLM) after systemic interleukin-1beta. In a subsequent experiment in which animals received parabrachial-directed deposits of a retrograde tracer, it was found that many neurons located in the nucleus tractus solitarius (NTS) and the VLM neurons were both retrogradely labelled and Fos-positive after interleukin-1beta administration. These results suggest that the parabrachial nucleus plays a critical role in interleukin-1beta-induced Fos expression in CeA, BNST and VLM neurons and that neurons of the NTS and VLM may serve to trigger or at least influence changes in parabrachial nucleus activity that follows systemic interleukin-1beta administration.

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Citations

Mar 14, 2009·Cellular and Molecular Neurobiology·Zdeno PirnikAlexander Kiss
Sep 10, 2013·Progress in Neurobiology·Paula J BruntonJonathan J Hirst
Mar 16, 2011·Physiology & Behavior·Michael S Bienkowski, Linda Rinaman
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