A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Sanjay PradhanLaura Timares

Abstract

Apoptosis plays an important role in eliminating UV-damaged keratinocytes, but its role in UV-induced immune suppression is not clear. Langerhans cells (LCs) may function as inducers of immune suppression. We have shown that LCs derived from mice deficient in the proapoptotic Bid (BH3-interacting death domain protein) gene (Bid KO) resist apoptosis and induce amplified immune responses. In this report, we examined responses in Bid KO mice to UVB exposure. Acute UV exposure led Bid KO mice to develop fewer apoptotic cells and retain a greater fraction of LCs in the epidermal layer of skin in comparison to wild-type mice. Bid KO mice were also markedly resistant to local and systemic UV tolerance induction to hapten sensitization and contact hypersensitivity responses. Elicitation responses and inflammation at skin sensitization sites in UV-treated Bid KO mice were equal to or greater than nonsuppressed control responses. In Bid KO mice, LCs accumulated in lymph nodes to greater numbers, demonstrated longer lifespans, and contained fewer DNA-damaged cells. These studies provide evidence that Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and that its absence abrogates UV-induced immune ...Continue Reading

References

Oct 1, 1989·The Journal of Experimental Medicine·L A ApplegateM L Kripke
Dec 22, 1994·Nature·A ZieglerD E Brash
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·C NishigoriM L Kripke
Oct 1, 1996·The Journal of Investigative Dermatology·S BeissertR D Granstein
Apr 20, 1999·The Journal of Experimental Medicine·L L HillL B Owen-Schaub
Aug 6, 1999·Oncogene·W JiangM L Kripke
Jan 10, 2002·Nature Cell Biology·Agatha SchwarzThomas Schwarz
Mar 16, 2002·Neoplasia : an International Journal for Oncology Research·Maryla KrajewskaStanislaw Krajewski
Oct 29, 2002·Nature Cell Biology·Joanna K SaxWafik S El-Deiry
Jan 10, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Brian J NickoloffMitchell F Denning
Jan 21, 2003·Genes & Development·Sandra S ZinkelStanley J Korsmeyer
Oct 18, 2003·Seminars in Immunology·Bryan C BarnhartMarcus E Peter
Jan 28, 2004·Cell·Nika N Danial, Stanley J Korsmeyer
May 12, 2004·Journal of Cellular Physiology·Jian-Zhong QinBrian J Nickoloff
Jan 20, 2005·The Journal of Experimental Medicine·Agatha SchwarzThomas Schwarz
Aug 27, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Nicole SchadeJean Krutmann
Jan 19, 2006·The Journal of Investigative Dermatology·Stefan BeissertThomas Schwarz
Jan 19, 2006·The Journal of Investigative Dermatology·Deepak RajDouglas Grossman
May 25, 2006·Photodermatology, Photoimmunology & Photomedicine·Motoko HamakawaTakeshi Horio
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay PradhanLaura Timares
Dec 5, 2006·Nature Medicine·Karin LoserStefan Beissert
Apr 20, 2007·Molecular Carcinogenesis·Stephen E Ullrich
Dec 19, 2007·The Journal of Experimental Medicine·Lionel Franz PoulinBernard Malissen
Dec 19, 2007·The Journal of Experimental Medicine·Florent GinhouxMiriam Merad
Dec 19, 2007·The Journal of Experimental Medicine·Laura S BurschKristin A Hogquist
Feb 6, 2008·Photochemistry and Photobiology·Laura TimaresCraig A Elmets

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Citations

Oct 21, 2009·Apoptosis : an International Journal on Programmed Cell Death·Takayuki KojimaKazuichi Sakamoto
Apr 15, 2009·Nature Reviews. Immunology·Douglas R GreenGuido Kroemer
Jul 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul Kushwah, Jim Hu
Dec 22, 2010·Archives of Dermatological Research·Francesca PrignanoN Pimpinelli
Sep 13, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mayumi HatakeyamaChikako Nishigori
Oct 13, 2010·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Hsiang-Yin Chen, R Douglas Watson
Apr 27, 2019·International Journal of Molecular Sciences·Matthew J BottomleyIrene Leigh

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