A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development

Experimental Neurobiology
Sung-Tae Hong, Won Mah

Abstract

GIT1, a multifunctional signaling adaptor protein, is implicated in the development of dendritic spines and neuronal synapses. GIT1 forms a signaling complex with PIX, RAC, and PAK proteins that is known to play important roles in brain development. Here we found that Git1-knockout (Git1(-/-) ) mice show a microcephaly-like small brain phenotype, which appears to be caused by reduced neuronal size rather than number. Git1(-/-) mice also show decreased dendritic spine number without morphological alterations in the hippocampus. Behaviorally, Git1(-/-) mice show impaired motor coordination and learning and memory. In addition, adult dGit Drosophila mutants show decreased brain size and abnormal morphology of the mushroom body. These results suggest that GIT1 is important for brain development in both rodents and flies.

References

Jul 1, 1993·Neuron·R L Davis
Sep 10, 1998·Nature Genetics·K M AllenC A Walsh
Mar 23, 2001·Current Opinion in Neurology·G H Mochida, C A Walsh
Mar 29, 2002·Nature·Satoko Hakeda-SuzukiBarry J Dickson
Apr 16, 2003·The Journal of Cell Biology·Huaye ZhangAlan F Horwitz
Mar 17, 2004·Current Opinion in Neurobiology·C Geoffrey Woods
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Huaye ZhangAlan F Horwitz
Apr 7, 2006·Journal of Cell Science·Ryan J Hoefen, Bradford C Berk
Apr 25, 2006·Journal of Neurotrauma·Frank P T HamersElbert A J Joosten
Feb 21, 2007·Nature Neuroscience·Inmaculada SeguraAmparo Acker-Palmer
Sep 14, 2007·American Journal of Medical Genetics. Part a·Maarit PeippoIrma Järvelä
Jan 19, 2008·American Journal of Medical Genetics. Part a·Joanna Walczak-SztulpaAndreas Tzschach
Apr 23, 2009·Neuroscience Letters·Robert SchmalzigaugRichard T Premont
Apr 19, 2011·Nature Medicine·Hyejung WonEunjoon Kim
Jun 3, 2014·Cell Reports·Jasmin PodufallVolker Haucke
Jul 11, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura A KehoeDominique Muller
Aug 21, 2014·Molecular and Cellular Biochemistry·T J SheuBradford C Berk

❮ Previous
Next ❯

Citations

Apr 3, 2016·Acta Neuropathologica Communications·Sarika SrivastavaKonark Mukherjee
Apr 30, 2016·Neural Regeneration Research·Yi-Sheng LiWei-Qiang Gao
Jun 19, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jian ChenGuo-Yong Yin
Jul 2, 2016·Scientific Reports·Mohammed UddinStephen W Scherer
Jun 14, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shoko EdogawaMadhusudan Grover
Apr 3, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Idoia Blanco-LuquinMaite Mendioroz
Oct 4, 2020·Magnetic Resonance Imaging·Alexandra BadeaRichard T Premont
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Xingqiao XieZhiyi Wei
May 22, 2021·ACS Infectious Diseases·Nathanael D ReynoldsPatricia M Legler

❮ Previous
Next ❯

Methods Mentioned

BETA
gene trapping

Software Mentioned

Catwalk
Excel
ImageJ
R
MetaMorph

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Maïté M MoreauNathalie Sans
The Journal of Cell Biology
Huaye ZhangAlan F Horwitz
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Huaye ZhangAlan F Horwitz
© 2021 Meta ULC. All rights reserved