Dec 1, 1977

A cross-reaction between beta2-microglobulin and kappa-light chains

The Journal of Immunology : Official Journal of the American Association of Immunologists
A B GottliebD Pressman


Certain antisera to immunoglobulins containing kappa-chains show the presence of antibodies that cross-react with beta2-microglobulin. This was most apparent with an antiserum made to highly purified F(ab) fragments of Fr II gamma-globulin. These cross-reactive antibodies caused positive fluorescence and cytotoxicity reactions with a variety of cell types including T cells. These reactions were completely removed by absorption with highly purified kappa-chains but not with lambda-chains or lambda immunoglobulins. beta2-microglobulin preparations also absorbed or inhibited the special cellular reactivities. Evidence was obtained that HLA-bound beta2-microglobulin was more efficient in this respect. The possibility is discussed that similar cross-reactive antibodies may have been involved in some previous studies of inhibition of T cell function by immunoglobulin antisera.

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Mentioned in this Paper

Immunofluorescence Assay
Immunoglobulin Activity
Immune Sera
Process of Absorption
Cross Reactions
Immunoglobulin Light Chains

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