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A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

The Journal of Infectious Diseases

Nov 4, 2019

Chad E MireChristopher C Broder

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Abstract

Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animals and humans. There are no approved vaccines or treatments for use in humans; however, therapeutic treatment of both NiV and HeV infection in ferrets and nonhuman primates with ...read more

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Monoclonal Antibodies
Epitopes
Cross Reactions
Combination Drug Therapy
Ferrets
Glycoproteins
Guanosine
Membrane Fusion
Nasal Provocation Tests
Physiological Aspects
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A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection

The Journal of Infectious Diseases

Nov 4, 2019

Chad E MireChristopher C Broder

PMID: 31686101

DOI: 10.1093/infdis/jiz515

Abstract

Nipah virus (NiV) and Hendra virus (HeV) are zoonotic paramyxoviruses that cause severe disease in both animals and humans. There are no approved vaccines or treatments for use in humans; however, therapeutic treatment of both NiV and HeV infection in ferrets and nonhuman primates with ...read more

Mentioned in this Paper

Monoclonal Antibodies
Epitopes
Cross Reactions
Combination Drug Therapy
Ferrets

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