A cross-sectional and longitudinal study evaluating brain volumes, RNFL, and cognitive functions in MS patients and healthy controls

BMC Neurology
Jessica FrauEleonora Cocco

Abstract

The principal biomarker of neurodegeneration in multiple sclerosis (MS) is believed to be brain volume, which is associated with cognitive functions and retinal nerve fibre layer (RNFL). A cross-sectional and longitudinal assessment of the relationship between RNFL, cognitive functions and brain volume. At baseline, relapsing patients and healthy controls underwent 1.5 T MRI to estimate the normalized volume of brain (NBV), grey (NGV), white (NWV) and peripheral grey (pNGV) matter. Cognitive functions were evaluated by BICAMS, RNFL by Spectral-Domain OCT. Patients were re-evaluated after 12 months. Cognitive functions, brain volume, and RNFL differed between the group of 66 patients and that of 16 healthy controls. In the MS group, at baseline, an association was found between: p-NGV and symbol-digit (SDMT) (p = 0.022); temporal-RNFL and NBV (p = 0.007), NWV (p = 0.012), NGV (p = 0.048), and p-NGV (p = 0.021); papillo-macular bundle-RNFL and NBV (p = 0.013), NWV (p = 0.02), NGV (p = 0.049), and p-NGV (p = 0.032). Over the observational period, we found a reduction of brain volume (p < 0.001), average-RNFL (p = 0.001), temporal-RNFL (p = 0.006), and papillo-macular bundle-RNFL (p = 0.009). No association was found between OCT, M...Continue Reading

References

Dec 17, 2002·NeuroImage·Stephen M SmithNicola De Stefano
May 2, 2007·Neurology·Jorge SepulcrePablo Villoslada
Dec 7, 2007·Journal of the Neurological Sciences·Erica GrazioliMurali Ramanathan
Jun 25, 2008·Multiple Sclerosis : Clinical and Laboratory Research·J ToledoP Villoslada
Nov 15, 2008·Lancet Neurology·Nancy D Chiaravalloti, John DeLuca
Jul 8, 2010·Revue neurologique·C LamirelV Biousse
Sep 2, 2011·Human Brain Mapping·Marco BattagliniNicola De Stefano
Feb 2, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·K L YoungS Schippling
Jan 22, 2014·CNS Drugs·Nicola De StefanoBernd C Kieseier
Aug 7, 2014·European Neurology·Christian P KammChris H Polman
Feb 11, 2015·Lancet Neurology·Maria A RoccaUNKNOWN MAGNIMS Study Group
Nov 28, 2015·Neurodegenerative Disease Management·Dawn Langdon
Oct 16, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Luis RuanoMaria Pia Amato
Apr 11, 2017·Neuroimaging Clinics of North America·Jaume Sastre-GarrigaÀlex Rovira
Jun 2, 2017·Journal of Neurology·Josefine BritzeJette Lautrup Frederiksen

❮ Previous
Next ❯

Citations

Dec 11, 2020·Multiple Sclerosis and Related Disorders·Ellen SkorveKjell-Morten Myhr
Jan 2, 2021·Translational Vision Science & Technology·Gulfidan BitirgenRayaz A Malik
Feb 3, 2020·Multiple Sclerosis and Related Disorders·Staley A Brod
Feb 15, 2020·Brain Research·Leila RaeesmohammadiMohammad Reza Motamed
May 29, 2021·Neurology. Neuroimmunology and Neuroinflammation·Sharon Jean BaetgeIris-Katharina Penner
Nov 19, 2021·Annals of Clinical and Translational Neurology·Friedemann PaulAxel Petzold

❮ Previous
Next ❯

Software Mentioned

BICAMS
Stata
SIENA
SIENAX
SIENA ( structural image evaluation using normalization of )
TrueTrac

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
K L YoungSven Schippling
Multiple Sclerosis : Clinical and Laboratory Research
Alex P LangeHelen Tremlett
Archivos de la Sociedad Española de Oftalmología
Elena Garcia-MartinIsabel Dolz
© 2022 Meta ULC. All rights reserved