A cross sectional study of bone and cartilage biomarkers: correlation with structural damage in rheumatoid arthritis

The Libyan Journal of Medicine
Wael Ben AchourElhem Cheour

Abstract

The aim of our study was to assess the relationship between bone and cartilage remodeling biomarkers and joint damage in Rheumatoid Arthritis (RA), and to detect whether they have the capacity to predict the progression of joint disease assessment by computed tomography (CT) erosion score. We analyzed 65 female patients with established RA in our Rheumatology Department. Serum levels of bone and cartilage markers were measured: osteocalcin (OC), N-propeptide of type I collagen (PINP), collagen type I and II, C-telopeptide (CTX I, CTX-II) and cartilage oligomeric matrix protein (COMP). Radiography of both wrist and MCP joints were available. Two expert-readers independently scored articular damage and progression using the High-resolution low dose CT scan in a blinded fashion. 65 female patients with established RA with a median age of 44 years were included. The median disease-duration was two years and the median (Disease activity score) DAS 28 score at 4.46 [2.65-7.36]. The percentage of patient with low disease activity was 13.8%, while 55.4 and 30.8% for those with moderate and high disease activity respectively. The resorption bone markers were high in active versus non-active RA. Wrist and MCP erosion scores were also ass...Continue Reading

References

Nov 1, 1995·British Journal of Rheumatology·D M van der Heijde
Nov 14, 1997·Seminars in Arthritis and Rheumatism·A M Abdel-NasserH A Valkenburg
Feb 24, 2001·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M J Seibel
May 16, 2003·Nature·Gary S Firestein
Jan 14, 2005·Annals of the Rheumatic Diseases·M ØstergaardP Conaghan
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Dec 6, 2011·Best Practice & Research. Clinical Rheumatology·York Kiat Tan, Philip G Conaghan
Jun 5, 2013·The Journal of Rheumatology·Annemarie KrabbenAnnette H M van der Helm-van Mil

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Citations

Feb 12, 2020·International Journal of Molecular Sciences·Chia-Chun TsengPo-Lin Kuo
Mar 31, 2021·Expert Review of Proteomics·Anne C Bay-JensenClaus H Nielsen
Jun 2, 2021·Auto- Immunity Highlights·Yolima Puentes-OsorioDaniel Taborda
Jun 4, 2021·Seminars in Musculoskeletal Radiology·Iwona Sudoł-SzopińskaAnne Cotten
Oct 27, 2021·Journal of Research in Health Sciences·Ravibabu KalahasthiTapu Barman

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Methods Mentioned

BETA
sandwich immunoassay

Software Mentioned

OSIRIX
SPSS
OMERACT RAMRIS

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