Abstract
Identifying metabolite signatures associated with obesity and related diseases might represent a valuable preventive and therapeutic tool to predict subjects at risk, establish an accurate prognosis, and monitor treatment success. The current cross-sectional study is aimed to evaluate the metabolite profile of diet-induced obesity in a porcine model of leptin resistance. Six Iberian female pigs prone to develop obesity (OB) were ad libitum fed a fat-enriched diet (HFD) for 82 days. Five lean Iberian sows (CON) in a maintenance diet served as controls. At the end of the dietary treatments, all animals were sacrificed, and plasma, liver, and muscle samples were immediately collected for nuclear magnetic resonance analysis. In plasma, signals corresponding to betaine, glycerophosphocholine/phosphocholine, glycine, and glutamate were decreased; and the valine signal was increased in OB sows compared to controls. Similarly, the betaine signal was decreased in the liver. No differences were detected in muscle. The observed metabolite changes suggest alterations in branched chain amino-acid metabolism and the methionine-homocysteine cycle, which have been previously associated with obesity-related diseases and type 2 diabetes in human...Continue Reading
References
Nov 25, 2004·Metabolism: Clinical and Experimental·Michael LeverStephen T Chambers
Nov 8, 2008·Mayo Clinic Proceedings·Linda L HumphreyMark Helfand
Apr 10, 2009·Cell Metabolism·Christopher B NewgardLaura P Svetkey
May 7, 2010·Journal of Inherited Metabolic Disease·Per Magne Ueland
Jun 12, 2010·Nature Protocols·Olaf BeckonertJeremy K Nicholson
Nov 9, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T TzotzasD N Kiortsis
Mar 23, 2011·Nature Medicine·Thomas J WangRobert E Gerszten
Apr 13, 2012·Circulation·Susan ChengThomas J Wang
May 26, 2012·TheScientificWorldJournal·L Torres-RoviraA Gonzalez-Bulnes
May 31, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B L HeitmannM S Westerterp-Plantenga
Apr 25, 2014·Amino Acids·Jason M CholewaNelo Eidy Zanchi
Aug 26, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y-M ChenH-L Zhu
Jan 7, 2016·PloS One·Timothy G BromageFriedemann Schrenk
Feb 10, 2016·Diabetes·Asma EjazCarles Lerin
Feb 11, 2016·Diabetes·Geoffrey A WalfordUNKNOWN Diabetes Prevention Program Research Group
May 12, 2016·PloS One·Xiang GaoGuang Sun
Jun 21, 2016·Current Diabetes Reports·Alba Gonzalez-FranquesaMary-Elizabeth Patti
Jan 26, 2018·Biochimie·Ciria G Figueroa-Soto, Elisa M Valenzuela-Soto
Jan 27, 2018·Nutrients·Jingjing DuLi Zhu
Feb 9, 2018·Disease Models & Mechanisms·Carolin PerlebergAngelika Schnieke
Mar 2, 2018·Journal of Proteome Research·Minoo BagheriAbolghasem Djazayery