A cross-sectional study on trans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI

The British Journal of Nutrition
Birgit M NielsenTine Jess

Abstract

Intake of trans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m(2). Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10-90th percentile 0·0-1·0) and R-TFA intake of 0·9 g (10-90th percentile 0·4-1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among midd...Continue Reading

References

Jun 1, 1977·Journal of Chronic Diseases·S Sonne-Holm, T I Sorensen
Jun 1, 1977·Journal of Chronic Diseases·T I Sorensen, S Sonne-Holm
Apr 1, 1999·European Journal of Clinical Nutrition·K F HulshofG van Poppel
May 31, 2001·The American Journal of Clinical Nutrition·J SalmerónW C Willett
Aug 28, 2001·Diabetes Care·K A MeyerA R Folsom
Sep 15, 2001·The New England Journal of Medicine·F B HuW C Willett
Feb 12, 2002·Obesity Research·Eva BlackArne Astrup
Mar 5, 2002·Diabetes Care·Rob M van DamFrank B Hu
Jun 25, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·Y-W ParkD Gallagher
Mar 31, 2004·The American Journal of Clinical Nutrition·Dariush MozaffarianEric B Rimm
Jan 15, 2005·Current Opinion in Lipidology·Ronald P Mensink
Apr 13, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B BuemannA Astrup
May 4, 2005·The Journal of Nutrition·Anwar T MerchantUNKNOWN SHARE and SHARE-AP Investigators
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·E BlackT I A Sørensen
May 23, 2006·Atherosclerosis. Supplements·Steen StenderArne Astrup
May 23, 2006·Atherosclerosis. Supplements·Marianne U JakobsenJørn Dyerberg
Dec 14, 2007·International Journal of Epidemiology·Marianne U JakobsenBerit L Heitmann
Mar 11, 2008·The American Journal of Clinical Nutrition·Annie Motard-BélangerBenoît Lamarche
Mar 11, 2008·Progress in Lipid Research·Arja ErkkiläDavid E Laaksonen
Nov 1, 2008·PloS One·Kaisa SilanderLeena Peltonen
Nov 11, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Micha, D Mozaffarian
Dec 25, 2008·Current Opinion in Lipidology·Ronald P Mensink, Paul Nestel
Dec 26, 2008·Food & Nutrition Research·Steen StenderJørn Dyerberg
May 29, 2009·The American Journal of Clinical Nutrition·Anne-Laure TardyBéatrice Morio
Oct 16, 2009·The Journal of Nutrition·Birgit M NielsenBerit L Heitmann
May 14, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J-A GilbertA Astrup

❮ Previous
Next ❯

Citations

Apr 3, 2012·Public Health Nutrition·Bernt J von ScholtenTine Jess
Nov 2, 2019·Progress in Lipid Research·Carina A ValenzuelaPhilip C Calder
Jun 9, 2012·Current Opinion in Cardiology

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.