PMID: 11926513Apr 3, 2002Paper

A cross-sectional survey of 32 workers exposed to hexahydrophthalic and methylhexahydrophthalic anhydrides

Industrial Health
Kozo YokotaKyohei Yamaguchi

Abstract

The relation between exposure and sensitization or the appearance of symptoms of the eyes and airways was investigated in a cross-sectional study on 32 workers from a plant using epoxy resin with a mixture of hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) as a hardener. The main component in the hardener was HHPA, and the geometric mean concentrations of HHPA in the workplaces were extremely low (<40 microg/m3) in recent years, compared to the Occupational Exposure Limit-Ceiling for phthalic anhydride (2 mg/m3). However, specific IgE antibody to HHPA was detected in serum from 8 (25%) out of the workers: of those, 5 workers experienced symptoms of the eyes and nose during work (group sensitized symptomatic (SS)) and 3 workers did not (group sensitized nonsymptomatic (SN)). The other 24 workers had no signs of sensitization and did not complain of work-related symptoms. Based on occupational history and anamnestic data, it was concluded that one subject in the SS group and all the subjects in the SN group had been sensitized by higher exposures in the past. The symptoms of 4 subjects in the SS group occurred only when carrying out short-time, particular tasks (15-30 min) a few times a day, such ...Continue Reading

Citations

Sep 13, 2003·Sangyō eiseigaku zasshi = Journal of occupational health·Naomi MatsumotoToshiyuki Takakura
Apr 1, 2004·Journal of Environmental Monitoring : JEM·Pirkko PfäffliRitva Wirmoila
Jan 26, 2021·Frontiers in Public Health·M Abbas Virji, Laura Kurth

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