A crossroad of microRNAs and immediate early genes (IEGs) encoding oncogenic transcription factors in breast cancer.

Journal of Mammary Gland Biology and Neoplasia
Aldema Sas-ChenYosef Yarden

Abstract

Signaling networks are involved in development, as well as in malignancy of the mammary gland. Distinct external stimuli activate intricate signaling cascades, which culminate in the activation of specific transcriptional programs. These signal-specific transcriptional programs are instigated by transcription factors (TFs) encoded by the immediate early genes (IEGs), and they lead to diverse cellular outcomes, including oncogenesis. Hence, regulating the expression of IEGs is of great importance, and involves several complementary transcriptional and posttranscriptional mechanisms, the latter entails also microRNAs (miRNAs). miRNAs are a class of non-coding RNAs, which have been implicated in regulation of various aspects of signaling networks. Through examination of the basic characteristics of miRNA function, we highlight the benefits of using miRNAs as regulators of early TFs and signaling networks. We further focus on the role of miRNAs as regulators of IEGs, which shape the initial steps of signaling-induced transcription. We especially emphasize the role of miRNAs in buffering external noise and maintaining low basal activation of IEGs in the absence of proper stimuli.

References

Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L F Lau, D Nathans
Aug 26, 1998·Molecular and Cellular Biology·J R BrownM E Greenberg
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Feb 20, 2003·RNA·Victor AmbrosThomas Tuschl
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
May 25, 2004·Genes & Development·Séverine Chambeyron, Wendy A Bickmore
Aug 21, 2004·Breast Cancer Research and Treatment·Karin Milde-LangoschAna-Maria Bamberger
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell
Sep 21, 2004·Oncogene·Hirofumi KawakuboShyamala Maheswaran
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ivan BiècheRosette Lidereau
Nov 3, 2004·Nature Reviews. Genetics·Hiroaki Kitano
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
Aug 17, 2005·Cancer Research·Marilena V IorioCarlo M Croce
Nov 15, 2005·Nature Cell Biology·Andrew JakymiwEdward K L Chan
Feb 17, 2006·BMC Genomics·Jana HertelUNKNOWN Students of Bioinformatics Computer Labs 2004 and 2005
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Ami Citri, Yosef Yarden
Sep 26, 2006·Nucleic Acids Research·Dominique A Glauser, Werner Schlegel
Oct 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Heon-Jin LeeW Scott Young
Feb 27, 2007·Nature Genetics·Ido AmitYosef Yarden
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitsuo KatoRama Natarajan
Mar 21, 2007·Genes & Development·Tobias M Franks, Jens Lykke-Andersen
Mar 27, 2007·Cold Spring Harbor Symposia on Quantitative Biology·S N BhattacharyyaW Filipowicz
Apr 4, 2007·Oncogene·J L MottG J Gores
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Cinzia SevignaniLinda D Siracusa
May 19, 2007·Nature Reviews. Genetics·Uri Alon
May 25, 2007·Nature·Peter Fraser, Wendy Bickmore
Jun 15, 2007·Molecular Cell·John TsangAlexander van Oudenaarden
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francesco TurturroEllen Friday
Jun 19, 2007·The Journal of Biological Chemistry·John W TullaiGeoffrey M Cooper
Jun 23, 2007·RNA·Nanna Rønbjerg ChristoffersenAnders H Lund
Aug 24, 2007·PLoS Biology·Erel LevineTerence Hwa
Oct 24, 2007·Cellular and Molecular Life Sciences : CMLS·F LaniganW M Gallagher
Jan 11, 2008·Nature·Sohail F TavazoieJoan Massagué

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Citations

Jul 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Landon WarkThomas Klonisch
May 9, 2014·Physiology & Behavior·Ibrahim M Hegab, Wanhong Wei
May 27, 2014·Biochemical and Biophysical Research Communications·Mellissa HicksJames DeWille
Apr 18, 2015·PLoS Computational Biology·Stuart AitkenColin A Semple
May 9, 2014·Oncotarget·Emanuela MinnaMaria Grazia Borrello

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